National Engineering Research Center for Functional Food, Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province, School of Food Science and Technology, Jiangnan University, Wuxi 214122, China.
Department of Food Science, Rutgers, The State University of New Jersey, 65 Dudley Road, New Brunswick, NJ 08901, USA.
Food Funct. 2024 Aug 27;15(17):8629-8643. doi: 10.1039/d3fo03892k.
Resveratrol is a non-flavonoid polyphenolic compound with numerous functional properties, such as anticancer, anti-inflammation, anti-oxidation, anti-obesity and more. However, resveratrol's poor solubility within aqueous media and low stability usually lead to compromised bioavailability, ultimately limiting its uptake and applications. Nanodelivery technologies have been studied intensively due to their potential in effectively improving resveratrol properties, thereby providing promising solutions for enhancing the bioavailability of resveratrol. Thus, this article aimed to review the recent advances of resveratrol nanodelivery systems, specifically on the types of nanodelivery systems, the corresponding preparation principles, advantages, as well as potential limitations associated. Meanwhile, studies have also found that coupled with nanodelivery systems, the functional properties of resveratrol could trigger apoptosis in cancer cells and inflammatory cells through various signaling pathways. Therefore, this article will also lead into discussions on the application aspects of resveratrol nanodelivery systems, emphasizing toward the fields of biomedical and food sciences. Potential pitfalls of resveratrol nanodelivery systems, such as issues with toxicity and target release, as well as outlooks regarding resveratrol nanodelivery systems are included in the Conclusion section, in the hope to provide insights for relevant future research.
白藜芦醇是一种非黄酮类多酚化合物，具有许多功能特性，如抗癌、抗炎、抗氧化、抗肥胖等。然而，白藜芦醇在水介质中的溶解度差和稳定性低通常会导致生物利用度降低，最终限制其吸收和应用。由于纳米递药技术在有效改善白藜芦醇性质方面的潜力，因此受到了广泛关注，为提高白藜芦醇的生物利用度提供了有前景的解决方案。因此，本文旨在综述白藜芦醇纳米递药系统的最新进展，特别是关于纳米递药系统的类型、相应的制备原理、优点以及潜在的局限性。同时，研究还发现，与纳米递药系统结合后，白藜芦醇的功能特性可以通过各种信号通路触发癌细胞和炎症细胞的凋亡。因此，本文还将讨论白藜芦醇纳米递药系统的应用方面，重点关注生物医学和食品科学领域。在结论部分还包括了白藜芦醇纳米递药系统的潜在问题，如毒性和靶向释放问题，以及对白藜芦醇纳米递药系统的展望，希望为相关的未来研究提供思路。
