Department of Drug Discovery and Development, Auburn University, Auburn, Alabama, USA.
Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Ajman University, Ajman, United Arab Emirates.
Cancer Rep (Hoboken). 2021 Jun;4(3):e1353. doi: 10.1002/cnr2.1353. Epub 2021 Mar 2.
Resveratrol (3, 5, 4 -trihydroxystilbene), a natural polyphenol and phytoalexin, has drawn considerable attention in the past decade due to its wide variety of therapeutic activities such as anticancer, anti-inflammatory, and antioxidant properties. However, its poor water solubility, low chemical stability, and short biological half-life limit its clinical utility.
Nanoparticles overcome the limitations associated with conventional chemotherapeutic drugs, such as limited availability of drugs to the tumor tissues, high systemic exposures, and consequent toxicity to healthy tissues. This review focuses on the physicochemical properties of resveratrol, the therapeutic potential of resveratrol nano-formulations, and the anticancer activity of resveratrol encapsulated nanoparticles on various malignancies such as skin, breast, prostate, colon, liver, ovarian, and lung cancers (focusing on both in vitro and in vivo studies).
Nanotechnology approaches have been extensively utilized to achieve higher solubility, improved oral bioavailability, enhanced stability, and controlled release of resveratrol. The resveratrol nanoparticles have markedly enhanced its anticancer activity both in vitro and in vivo, thus considering it as a potential strategy to fight various cancers.
白藜芦醇（3,5,4-三羟基二苯乙烯）是一种天然多酚和植物抗毒素，由于其广泛的治疗活性，如抗癌、抗炎和抗氧化特性，在过去十年中引起了相当大的关注。然而，其较差的水溶性、低化学稳定性和短的生物半衰期限制了其临床应用。
纳米粒子克服了与传统化疗药物相关的限制，例如药物在肿瘤组织中的有限可用性、全身暴露量高以及对健康组织的毒性。本综述重点介绍了白藜芦醇的物理化学性质、白藜芦醇纳米制剂的治疗潜力以及包封在纳米粒子中的白藜芦醇对各种恶性肿瘤（如皮肤、乳腺、前列腺、结肠、肝、卵巢和肺癌）的抗癌活性（重点关注体外和体内研究）。
纳米技术方法已被广泛用于实现更高的溶解度、改善口服生物利用度、增强稳定性和控制白藜芦醇的释放。白藜芦醇纳米粒子在体外和体内显著增强了其抗癌活性，因此被认为是对抗各种癌症的一种潜在策略。
