Laboratory of Neuro Imaging (LONI), Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, California, USA.
Alzheimers Dement. 2024 Oct;20(10):7320-7330. doi: 10.1002/alz.14099. Epub 2024 Aug 14.
The Alzheimer's Disease Neuroimaging Initiative (ADNI) has revolutionized the landscape of Alzheimer's research through its Informatics Core, which has facilitated unprecedented data standardization and sharing. Over 20 years, ADNI established a robust informatics framework, enabling the validation of biomarkers and supporting global research efforts. The Informatics Core, centered at the Laboratory of Neuro Imaging (LONI), provides a comprehensive data hub that ensures data quality, accessibility, and security, fostering over 5600 publications and significant scientific advancements. By embracing open data sharing principles, ADNI set a gold standard in data transparency, allowing over 26,000 investigators from 169 countries to access and download a wealth of multimodal data. This collaborative approach not only accelerated biomarker discovery and drug development and advanced our understanding of Alzheimer's disease but also has served as a model for other research initiatives, demonstrating the transformative potential of carefully designed informatics models and shared data in driving global scientific progress. HIGHLIGHTS: Accelerating biomarker discovery and drug development for Alzheimer's disease. Alzheimer's Disease Neuroimaging Initiative's (ADNI's) open data sharing drives scientific progress. Data exploration and coupled analytics to data archives.
阿尔茨海默病神经影像学倡议 (ADNI) 通过其信息学核心彻底改变了阿尔茨海默病研究的格局，该核心促进了前所未有的数据标准化和共享。在 20 多年的时间里，ADNI 建立了一个强大的信息学框架，验证了生物标志物，并支持了全球的研究工作。信息学核心以神经影像实验室 (LONI) 为中心，提供了一个全面的数据中心，确保了数据的质量、可访问性和安全性，促成了超过 5600 篇论文的发表和重大科学进展。通过采用开放数据共享原则，ADNI 树立了数据透明度的黄金标准，允许来自 169 个国家的超过 26000 名研究人员访问和下载大量多模态数据。这种合作方法不仅加速了阿尔茨海默病的生物标志物发现和药物开发，增进了我们对阿尔茨海默病的理解，而且为其他研究计划树立了榜样，展示了精心设计的信息学模型和共享数据在推动全球科学进步方面的变革潜力。亮点：加速阿尔茨海默病的生物标志物发现和药物开发。阿尔茨海默病神经影像学倡议 (ADNI) 的开放数据共享推动了科学进步。数据探索和耦合分析到数据档案。
