Department of Public Health Sciences, University of California, Davis, California, USA.
Department of Neurology, University of Southern California, Los Angeles, California, USA.
Alzheimers Dement. 2024 Oct;20(10):7331-7339. doi: 10.1002/alz.14159. Epub 2024 Aug 14.
The goal of the Biostatistics Core of the Alzheimer's Disease Neuroimaging Initiative (ADNI) has been to ensure that sound study designs and statistical methods are used to meet the overall goals of ADNI. We have supported the creation of a well-validated and well-curated longitudinal database of clinical and biomarker information on ADNI participants and helped to make this accessible and usable for researchers. We have developed a statistical methodology for characterizing the trajectories of clinical and biomarker change for ADNI participants across the spectrum from cognitively normal to dementia, including multivariate patterns and evidence for heterogeneity in cognitive aging. We have applied these methods and adapted them to improve clinical trial design. ADNI-4 will offer us a chance to help extend these efforts to a more diverse cohort with an even richer panel of biomarker data to support better knowledge of and treatment for Alzheimer's disease and related dementias. HIGHLIGHTS: The Alzheimer's Disease Neuroimaging Initiative (ADNI) Biostatistics Core provides study design and analytic support to ADNI investigators. Core members develop and apply novel statistical methodology to work with ADNI data and support clinical trial design. The Core contributes to the standardization, validation, and harmonization of biomarker data. The Core serves as a resource to the wider research community to address questions related to the data and study as a whole.
阿尔茨海默病神经影像学倡议（ADNI）的生物统计学核心的目标是确保使用合理的研究设计和统计方法来实现 ADNI 的总体目标。我们支持创建一个经过良好验证和精心管理的 ADNI 参与者的临床和生物标志物信息的纵向数据库，并帮助研究人员能够访问和使用该数据库。我们已经开发了一种统计方法，用于描述 ADNI 参与者从认知正常到痴呆的临床和生物标志物变化轨迹，包括多变量模式和认知老化异质性的证据。我们已经应用了这些方法并对其进行了改编，以改进临床试验设计。ADNI-4 将为我们提供一个机会，帮助将这些努力扩展到一个更具多样性的队列，其中包含更丰富的生物标志物数据面板，以支持更好地了解和治疗阿尔茨海默病和相关痴呆症。 亮点：阿尔茨海默病神经影像学倡议（ADNI）生物统计学核心为 ADNI 研究人员提供研究设计和分析支持。核心成员开发并应用新的统计方法来处理 ADNI 数据并支持临床试验设计。核心为生物标志物数据的标准化、验证和协调做出贡献。核心作为资源服务于更广泛的研究社区，以解决与数据和整个研究相关的问题。
