姜黄提取物负载壳聚糖微球治疗胃肠疾病的潜力。
The potential of turmeric extract-loaded chitosan microparticles for the treatment of gastrointestinal disorders.
机构信息
Division of Biological Sciences, Faculty of Sciences, Prince of Songkla University, Songkhla, Thailand.
Drug Delivery System Excellence Center, Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Songkhla, Thailand.
出版信息
J Microencapsul. 2024 Nov;41(7):547-563. doi: 10.1080/02652048.2024.2390958. Epub 2024 Aug 14.
AIM
To develop turmeric extract-loaded chitosan microparticles for treating gastrointestinal disorders.
METHODS
The microparticles were prepared using a spray-drying process, optimised the characteristics by biomarker loading, and encapsulation efficiency, and assessed for bioactivities related to gastrointestinal diseases.
RESULTS
The optimised microparticles were spherical, with a mean diameter of 2.11 ± 0.34 µm, a SPAN of 4.46 ± 0.68, a zeta potential of +37.6 ± 0.2 mV, loading of 15.7% w/w curcuminoids, 5.4% w/w ar-turmerone, and encapsulation efficiency of 63.26 ± 1.62% w/w curcuminoids and 43.75 ± 1.33% w/w ar-turmerone. Encapsulation of turmeric extract improved release at 6 h by 20 times and mucoadhesion by 3.6 times. The microparticles exhibited high acid-neutralising capacity (1.64 ± 0.34 mEq/g) and inhibited nitric oxide production about twice as effectively as the turmeric extract, while maintaining antioxidant and antibacterial activities.
CONCLUSION
Encapsulation of turmeric extract in chitosan microparticles effectively enhanced therapeutic potential for gastrointestinal disorders.
目的
开发负载姜黄提取物的壳聚糖微球用于治疗胃肠道疾病。
方法
采用喷雾干燥法制备微球，通过生物标志物负载和包封效率优化其特性，并评估其与胃肠道疾病相关的生物活性。
结果
优化后的微球呈球形，平均直径为 2.11±0.34μm，SPAN 为 4.46±0.68，Zeta 电位为+37.6±0.2mV，载药量为 15.7%w/w 姜黄素、5.4%w/w 莪术酮，包封效率为 63.26±1.62%w/w 姜黄素和 43.75±1.33%w/w 莪术酮。姜黄提取物的包封显著提高了 6 小时的释放量，提高了 20 倍，提高了 3.6 倍的粘膜粘附性。微球具有较高的中和胃酸能力（1.64±0.34 mEq/g），其抑制一氧化氮生成的效果约为姜黄提取物的两倍，同时保持抗氧化和抗菌活性。
结论
壳聚糖微球包封姜黄提取物可有效增强其治疗胃肠道疾病的潜力。
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