Department of Food and Nutrition, Hanyang University, Seoul, Republic of Korea.
J Agric Food Chem. 2010 Mar 24;58(6):3316-21. doi: 10.1021/jf904091d.
Elsholtzia splendens extract-loaded chitosan nanoparticles prepared by ionic gelation were characterized by particle size, zeta potential, entrapment efficiency, and loading efficiency. As the initial concentration of E. splendens extract was increased, the loading efficiency and zeta potential significantly increased, whereas the entrapment efficiency and particle size significantly decreased. The optimum concentration of E. splendens extract for maximum loading efficiency was found to be 0.8 mg/mL. Both free E. splendens extract and E. splendens extract-loaded chitosan nanoparticles showed concentration-dependent antioxidant activity. However, the lipid peroxidation inhibitory activity of E. splendens extract was effectively enhanced when it was entrapped within chitosan nanoparticles. Chitosan nanoparticle encapsulation is therefore a potentially valuable technique for improving the antioxidant activity of E. splendens extract.
采用离子凝胶法制备的罗勒提取物负载壳聚糖纳米粒子的特征在于粒径、Zeta 电位、包封效率和载药效率。随着罗勒提取物初始浓度的增加，载药效率和 Zeta 电位显著增加，而包封效率和粒径显著降低。发现罗勒提取物的最佳浓度为 0.8mg/mL，此时载药效率最高。游离罗勒提取物和罗勒提取物负载壳聚糖纳米粒子均表现出浓度依赖性抗氧化活性。然而，当罗勒提取物被包封在壳聚糖纳米粒子内时，其抑制脂质过氧化的活性得到有效增强。因此，壳聚糖纳米粒子包封是提高罗勒提取物抗氧化活性的一种有价值的技术。
