细菌中核糖体合成及翻译后修饰肽（RiPPs）的基因组挖掘
Genome mining for ribosomally synthesized and post-translationally modified peptides (RiPPs) in bacteria.
作者信息
Al Mamun Abdullah, Alam Khorshed, Koly Farjana Akter, Showline Chaity Farjana, Ferdous Jannatul, Islam Saiful
机构信息
Bangladesh Council of Scientific and Industrial Research (BCSIR), Dhaka, Bangladesh.
Bangladesh Standards and Testing Institution (BSTI), Dhaka, Bangladesh.
出版信息
J Asian Nat Prod Res. 2025 Mar;27(3):354-367. doi: 10.1080/10286020.2024.2390510. Epub 2024 Aug 14.
Ribosomally synthesized post-translationally modified peptides (RiPPs) are a novel category of bioactive natural products (NPs). bacteria are a potential source of many bioactive NPs. Limited opportunities are available to characterize all the bioactive NP gene clusters. In this study, 410 sequences of were analyzed for RiPPs through genome mining using the National Center for Biotechnology Information (NCBI), by combining BAGEL and anti-SMASH. A total of 4098 RiPPs were found; including both classified (lanthipeptide, RiPP-like, bacteriocin, LAPs, lassopeptide, thiopeptides) and nonclassified RiPPs. Soil was identified as a rich habitat for RiPPs. These data may offer alternative future remedies for various health issues.
核糖体合成的翻译后修饰肽（RiPPs）是一类新型的生物活性天然产物（NPs）。细菌是许多生物活性NPs的潜在来源。表征所有生物活性NP基因簇的机会有限。在本研究中，通过结合BAGEL和抗SMASH，利用美国国立生物技术信息中心（NCBI）通过基因组挖掘分析了410个序列中的RiPPs。共发现4098个RiPPs；包括已分类的（羊毛硫肽、类RiPP、细菌素、LAPs、lassopeptide、硫肽）和未分类的RiPPs。土壤被确定为RiPPs的丰富栖息地。这些数据可能为各种健康问题提供未来的替代疗法。
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