Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
Diabetes and Metabolic Disease Clinical Research Center of Hubei Province, Wuhan, People's Republic of China.
Am J Physiol Endocrinol Metab. 2024 Oct 1;327(4):E411-E421. doi: 10.1152/ajpendo.00154.2024. Epub 2024 Aug 14.
Perineuronal nets (PNNs), specialized extracellular matrix (ECM) structures that envelop neurons, have recently been recognized as key players in the regulation of metabolism. This review explores the growing body of knowledge concerning PNNs and their role in metabolic control, drawing insights from recent research and relevant studies. The pivotal role of PNNs in the context of energy balance and whole body blood glucose is examined. This review also highlights novel findings, including the effects of astroglia, microglia, sex and gonadal hormones, nutritional regulation, circadian rhythms, and age on PNNs dynamics. These findings illuminate the complex and multifaceted role of PNNs in metabolic health.
周围神经毡（PNNs）是一种特殊的细胞外基质（ECM）结构，包裹神经元，最近被认为是调节代谢的关键因素。本综述探讨了关于 PNNs 及其在代谢控制中的作用的日益增多的知识，从最近的研究和相关研究中汲取了见解。研究检查了 PNNs 在能量平衡和全身血糖背景下的关键作用。本综述还强调了新的发现，包括星形胶质细胞、小胶质细胞、性别和性腺激素、营养调节、昼夜节律和年龄对 PNNs 动态的影响。这些发现阐明了 PNNs 在代谢健康中的复杂和多方面的作用。
