Department of Obstetrics and Gynecology, Affliated Hospital of Nantong University, Nantong, China.
Medical College, Nantong University, Nantong, China.
Clin Appl Thromb Hemost. 2024 Jan-Dec;30:10760296241266820. doi: 10.1177/10760296241266820.
Post-thrombotic syndrome (PTS) is one of the most common long-term complications of lower extremity deep vein thrombosis (DVT). In order to study the long-term adverse prognosis of patients with DVT, explore the influencing factors for the prognosis of DVT, and provide a reliable reference for future research in the field of venous thrombosis, we collected and summarized information about the incidence of PTS, the PTS score and grading, the associated symptoms and drug-related adverse reactions in 501 patients with DVT. In our study, 54.1% of patients with DVT (271 of 501) experienced indications and manifestations of PTS, the male to female ratio was approximately 1:1. During the long-term follow up, the most common symptoms of PTS were anterior tibial edema and pain. By statistical analysis, we found that the outcome of thrombosis was the influencing factor of PTS score (1-4 points, <.05). The grading of PTS was primarily influenced by the history of varicose veins and DVT in the lower extremities. The duration of taking antithrombotic drugs affected the outcome of thrombosis (<.05), especially among the female patients. In addition, varied factors, such as lower extremity DVT complicated with pulmonary embolism and the duration of antithrombotic drug use were found to increase the chances of experiencing drug-related adverse reactions (odds ratio [OR]=2.798, 95% confidence interval [CI]: 1.413-5.541 / OR=2.778, 95% CI: 1.231-6.269). The above 2 factors were significant only among female patients with DVT (OR=4.03, 95% CI: 1.608-10.103 / OR=3.918, 95% CI: 1.123-13.669).
血栓后综合征（PTS）是下肢深静脉血栓（DVT）最常见的长期并发症之一。为了研究 DVT 患者的长期不良预后，探讨影响 DVT 预后的因素，为静脉血栓领域的未来研究提供可靠的参考，我们收集并总结了 501 例 DVT 患者 PTS 的发生率、PTS 评分和分级、相关症状和药物相关不良反应的信息。在我们的研究中，54.1%（271/501）的 DVT 患者出现 PTS 的指征和表现，男女比例约为 1:1。在长期随访中，PTS 最常见的症状是胫骨前水肿和疼痛。通过统计分析，我们发现血栓形成的结果是 PTS 评分的影响因素（1-4 分，<.05）。PTS 的分级主要受下肢静脉曲张和 DVT 的病史影响。抗血栓药物的使用时间影响血栓形成的结果（<.05），尤其是女性患者。此外，还发现下肢 DVT 合并肺栓塞、抗血栓药物使用时间等因素会增加药物相关不良反应的发生几率（比值比[OR]=2.798，95%置信区间[CI]：1.413-5.541/OR=2.778，95% CI：1.231-6.269）。这两个因素仅在女性 DVT 患者中具有统计学意义（OR=4.03，95% CI：1.608-10.103/OR=3.918，95% CI：1.123-13.669）。
