Farris R L
Trans Am Ophthalmol Soc. 1985;83:501-45.
Tear analysis in contact lens wearers was compared with tear analysis in aphakics without contact lens wear and normal phakic patients. Subjects were divided into five groups: group 1, aphakic without contact lens; group 2, phakic with daily-wear hard contact lens; group 3, phakic with daily-wear soft contact lens; group 4, phakic with extended-wear soft contact lens; and group 5, aphakic with extended-wear soft contact lens. The experimental groups were compared with age- and sex-matched control groups for statistical analysis of tear variables by means of the Student's t-test. The variables measured were tear osmolarity, tear albumin, and lysozyme and lactoferrin concentrations in basal and reflex tears. Highly significant elevations of tear osmolarity were found in aphakic subjects without contact lenses. Less significant differences in tear osmolarity were found in phakic subjects with hard daily-wear lenses or with extended-wear soft lenses. Tear albumin, lysozyme, and lactoferrin in basal and reflex tears were not significantly different in the different groups of contact lens wearers or in the group of aphakic subjects without contact lenses compared with their control groups. Individual variations in tear albumin, lysozyme, and lactoferrin appeared to be responsible for the inability to demonstrate significant differences in tear composition in association with the wearing of different types of contact lenses. Older and aphakic patients demonstrated a tendency to have increased concentrations of proteins in the tears compared with younger, phakic contact lens wearers and normal controls without contact lenses.
对佩戴隐形眼镜者的泪液分析与未佩戴隐形眼镜的无晶状体者及正常晶状体患者的泪液分析进行了比较。受试者被分为五组：第1组，无晶状体且未佩戴隐形眼镜；第2组，佩戴日戴型硬性隐形眼镜的有晶状体者；第3组，佩戴日戴型软性隐形眼镜的有晶状体者；第4组，佩戴长戴型软性隐形眼镜的有晶状体者；第5组，佩戴长戴型软性隐形眼镜的无晶状体者。通过学生t检验对实验组与年龄和性别匹配的对照组进行泪液变量的统计分析。所测量的变量为基础泪液和反射泪液中的泪液渗透压、泪液白蛋白、溶菌酶和乳铁蛋白浓度。在未佩戴隐形眼镜的无晶状体受试者中发现泪液渗透压显著升高。在佩戴日戴型硬性隐形眼镜或长戴型软性隐形眼镜的有晶状体受试者中，泪液渗透压的差异较小。与对照组相比，不同组隐形眼镜佩戴者或未佩戴隐形眼镜的无晶状体受试者组的基础泪液和反射泪液中的泪液白蛋白、溶菌酶和乳铁蛋白无显著差异。泪液白蛋白、溶菌酶和乳铁蛋白的个体差异似乎是导致无法证明与佩戴不同类型隐形眼镜相关的泪液成分存在显著差异的原因。与年轻的有晶状体隐形眼镜佩戴者和未佩戴隐形眼镜的正常对照组相比，年龄较大的无晶状体患者泪液中蛋白质浓度有升高的趋势。
