Reele S B, Euler A R, Hanover C K, Lookabaugh J L
Acta Obstet Gynecol Scand. 1985;64(8):645-7. doi: 10.3109/00016348509158206.
Arbaprostil ((15R)-15-methyl Prostaglandin E2) is being studied for the treatment of gastrointestinal illness. To determine its effect on the human uterus, eight sterilized pre-menopausal women were studied during the proliferative phase of their menstrual cycle. Using a microtransducer catheter, intra-uterine pressures were recorded for at least 30 minutes prior to and 2 hours after arbaprostil administration. Each subject was studied four times, at 48-hour intervals, receiving in a double-blind manner; 0, 10, 25, and 50 micrograms. Arbaprostil at does up to 50 micrograms was found not to have any clinically significant effects on the non-pregnant human uterus.
阿巴前列素（(15R)-15-甲基前列腺素E2）正在进行治疗胃肠道疾病的研究。为确定其对人体子宫的影响，在8名绝育的绝经前妇女月经周期的增殖期进行了研究。使用微型换能器导管，在给予阿巴前列素之前至少30分钟和给药后2小时记录子宫内压力。每个受试者每隔48小时接受4次研究，采用双盲方式给予0、10、25和50微克药物。结果发现，剂量高达50微克的阿巴前列素对未孕人体子宫没有任何临床显著影响。
