Reele S B, Nauss-Karol C, Lusaitis A A, Passe S M
Department of Clinical Research and Development, Hoffmann-La Roche Inc., Nutley, NJ 07110.
Clin Pharmacol Ther. 1988 Aug;44(2):179-85. doi: 10.1038/clpt.1988.134.
Prostaglandin E2 is uterotonic. Trimoprostil, a prostaglandin E2 analog, is a gastric antisecretory and cytoprotective agent. The effects of single doses of 0, 0.125, 0.75, and 3.0 mg trimoprostil on intrauterine pressure were measured in a double-blind, crossover study in eight surgically sterile women. The 3 mg dose was not tolerated because of abdominal cramps. The other doses caused a dose-related increase in resting uterine tone and peak pressure with peak effect occurring between 30 and 60 minutes after administration with a duration of about 120 minutes. No effects on the frequency of uterine contractions occurred. Peak mean tone increased from 11.0 to 71.2 mm Hg (p less than 0.01) and peak pressure from 24.6 to 125.1 mm Hg (p less than 0.01) after placebo compared with the 1.5 mg dose. Adverse reactions included abdominal pain that correlated with an increase in intrauterine pressure and tone.
前列腺素E2具有子宫收缩作用。曲莫前列素是一种前列腺素E2类似物，是一种胃抗分泌和细胞保护剂。在一项针对8名手术绝育女性的双盲交叉研究中，测量了单剂量0、0.125、0.75和3.0毫克曲莫前列素对子宫内压的影响。3毫克剂量因腹部绞痛而无法耐受。其他剂量导致静息子宫张力和峰值压力呈剂量相关增加，给药后30至60分钟出现峰值效应，持续时间约120分钟。对子宫收缩频率无影响。与1.5毫克剂量相比，安慰剂后平均峰值张力从11.0毫米汞柱增加到71.2毫米汞柱（p小于0.01），峰值压力从24.6毫米汞柱增加到125.1毫米汞柱（p小于0.01）。不良反应包括与子宫内压和张力增加相关的腹痛。
