Department of Biological Applications and Technology, University of Ioannina, 45110 Ioannina, Greece.
Department of Biological Applications and Technology, University of Ioannina, 45110 Ioannina, Greece; Biomedical Research Institute, Foundation for Research and Technology-Hellas (FORTH), 45110 Ioannina, Greece; Institute of Biosciences, University of Ioannina, 45110 Ioannina, Greece.
Schizophr Res. 2024 Sep;271:380-390. doi: 10.1016/j.schres.2024.06.043. Epub 2024 Aug 13.
Multiomics approaches have significantly aided the identification of molecular signatures in complex neuropsychiatric disorders. Lipidomics, one of the newest additions in the -omics family, sheds light on lipid profiles and is an emerging methodological tool to study schizophrenia pathobiology, as lipid dysregulation has been repeatedly observed in schizophrenia. In this review, we performed a detailed literature search for lipidomics studies in schizophrenia. Following elaborate inclusion/exclusion criteria, we focused on human studies in schizophrenia and schizophrenia-related diagnoses in brain and blood specimens, including serum plasma, platelets and red blood cells. Eighteen studies fulfilled our inclusion criteria, of which five were conducted in the brain, 12 in peripheral material and one in both. Here, we first provide background on lipidomics and the main lipid categories addressed, review in detail the included literature and look for common lipidomics patterns in brain and the periphery that emerge from these studies. Furthermore, we highlight current limitations in schizophrenia lipidomics research and underline the need for following up on lipidomics results with complementary molecular approaches.
多组学方法极大地帮助了识别复杂神经精神疾病中的分子特征。脂质组学是组学家族中的最新成员之一，它揭示了脂质谱，并成为研究精神分裂症病理生物学的新兴方法学工具，因为脂质失调在精神分裂症中反复被观察到。在这篇综述中，我们对精神分裂症的脂质组学研究进行了详细的文献检索。经过精心的纳入/排除标准，我们专注于精神分裂症以及大脑和血液标本中的精神分裂症相关诊断的人类研究，包括血清血浆、血小板和红细胞。有 18 项研究符合我们的纳入标准，其中 5 项在大脑中进行，12 项在周围材料中进行，1 项在两者中进行。在这里，我们首先提供脂质组学的背景和所涉及的主要脂质类别，详细回顾所包括的文献，并寻找这些研究中从大脑和外周出现的常见脂质组学模式。此外，我们强调了精神分裂症脂质组学研究中的当前局限性，并强调需要用互补的分子方法跟进脂质组学结果。
