College of Chemistry and Materials Science, Hebei University, Baoding City, Hebei Province 071002, China.
College of Pharmaceutical Sciences, Hebei University, Baoding 071002, China; State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China.
Colloids Surf B Biointerfaces. 2024 Dec;244:114160. doi: 10.1016/j.colsurfb.2024.114160. Epub 2024 Aug 11.
The delay of diabetic wound healing puts a huge burden on the society. The key factors hindering wound healing include bacterial infection, unresolved inflammation and poorly generated blood vessels. In this paper, glycidyl trimethyl ammonium chloride (GTA) was grafted to chitosan (CS) to obtain quaternary ammonium grafted chitosan (QCS) with enhanced antibacterial performance, and then cross-linked by dialdehyde terminated poly(ethylene oxide) (PEO DA) to construct QCS/PEO DA hydrogel with tissue adhesion, biodegradation and self-healing properties. The QCS/PEO DA hydrogel is loaded with tannin acid (TA) and deferoxamine (DFO) to enhance antioxidant property and angiogenesis. At the same time, the TA and DFO loaded TA@DFO/hydrogel preserved the biocompatibility and biodegradability of chitosan. Moreover, the multifunctional hydrogel behaved excellent hemostatic properties in mice model and significantly promoted the healing efficacy of diabetic wounds. Overall, the TA@DFO/hydrogel is promising anti-infection dressing material for diabetic wound healing.
糖尿病伤口愈合的延迟给社会带来了巨大的负担。阻碍伤口愈合的关键因素包括细菌感染、未解决的炎症和血管生成不良。本文将缩水甘油三甲铵氯（GTA）接枝到壳聚糖（CS）上，得到具有增强抗菌性能的季铵化壳聚糖（QCS），然后用端醛基聚氧化乙烯（PEO DA）交联，构建具有组织粘附、可生物降解和自修复性能的 QCS/PEO DA 水凝胶。将单宁酸（TA）和去铁胺（DFO）负载到 QCS/PEO DA 水凝胶上，以增强抗氧化和血管生成能力。同时，负载 TA 和 DFO 的 TA@DFO/水凝胶保持了壳聚糖的生物相容性和可生物降解性。此外，多功能水凝胶在小鼠模型中表现出优异的止血性能，并显著促进糖尿病伤口的愈合效果。总的来说，TA@DFO/水凝胶有望成为治疗糖尿病伤口感染的新型敷料。
