Department of Microbiology, Centre for infectious Diseases, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University (Deemed to be University), Chennai, Tamil Nadu 600077, India.
Department of Microbiology, Centre for infectious Diseases, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University (Deemed to be University), Chennai, Tamil Nadu 600077, India.
Pathol Res Pract. 2024 Oct;262:155540. doi: 10.1016/j.prp.2024.155540. Epub 2024 Aug 12.
The PI3K/Akt pathway plays a critical role in the progression and treatment of oral squamous cell carcinoma (OSCC). Recent research has uncovered the involvement of long non-coding RNAs (lncRNAs) in regulating this pathway, influencing OSCC cell proliferation, survival, and metastasis. This review explores the latest findings on how certain lncRNAs act as either cancer promoters or cancer inhibitors within the PI3K/Akt signaling pathway. Certain lncRNAs act as oncogenic or tumor-suppressive agents, making them potential diagnostic and prognostic markers. Targeting these lncRNAs may lead to novel therapeutic strategies. The evolving fields of precision medicine and artificial intelligence promise advancements in OSCC diagnosis and treatment, enabling more personalized and effective patient care.
PI3K/Akt 通路在口腔鳞状细胞癌（OSCC）的进展和治疗中起着关键作用。最近的研究揭示了长非编码 RNA（lncRNA）在调节该通路中的作用，影响 OSCC 细胞的增殖、存活和转移。本综述探讨了特定 lncRNA 作为 PI3K/Akt 信号通路中的癌基因或抑癌基因的最新发现。某些 lncRNA 作为致癌或肿瘤抑制因子发挥作用，使它们成为潜在的诊断和预后标志物。针对这些 lncRNA 可能会导致新的治疗策略。精准医学和人工智能这两个不断发展的领域有望推动 OSCC 的诊断和治疗取得进展，实现更个性化和有效的患者护理。
