Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100193, China; State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Beijing, 100700, China.
Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100193, China.
Curr Opin Plant Biol. 2024 Oct;81:102616. doi: 10.1016/j.pbi.2024.102616. Epub 2024 Aug 13.
The phenomenon of multicellular compartmentation in biosynthetic pathways has been documented for only a limited subset of specialized metabolites, despite its hypothesized significance in facilitating plant survival and adaptation to environmental stress. Transporters that shuttle metabolic intermediates between cells are hypothesized to be integral components enabling compartmentalized biosynthesis. Nevertheless, our understanding of the multicellular compartmentation of plant specialized metabolism and the associated intermediate transporters remains incomplete. The emergence of single-cell and spatial multiomics techniques holds promise for shedding light on unresolved questions in this field, such as the prevalence of multicellular compartmentation across the plant kingdom and the specific types of specialized metabolites whose biosynthetic pathways are prone to compartmentation. Advancing our understanding of the mechanisms underlying multicellular compartmentation will contribute to improving the production of specialized target metabolites through metabolic engineering or synthetic biology.
尽管细胞分隔在生物合成途径中对于促进植物的生存和适应环境压力具有假设意义，但目前仅在有限的一部分特殊代谢物中记录到了这种现象。穿梭于细胞之间代谢中间产物的转运蛋白被假设是实现细胞分隔生物合成的组成部分。然而，我们对植物特殊代谢物的细胞分隔以及相关的中间转运蛋白的理解仍然不完整。单细胞和空间多组学技术的出现有望为解决该领域的未解决问题提供线索，例如细胞分隔在植物界中的普遍程度以及生物合成途径容易分隔的特殊代谢物的具体类型。深入了解细胞分隔的机制将有助于通过代谢工程或合成生物学提高特殊目标代谢物的产量。
