巨噬细胞深入研究癌症中的肥胖悖论。
Macrophages dig into the obesity paradox in cancer.
机构信息
Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA; Massachusetts General Hospital Cancer Center, Boston, MA, USA.
Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.
出版信息
Immunity. 2024 Aug 13;57(8):1731-1733. doi: 10.1016/j.immuni.2024.07.013.
Response to immune checkpoint blockade is increased in obesity-related cancers, but the mechanisms remain unclear. In a recent issue of Nature, Bader et al. report that obesity in mice induces macrophage PD-1 upregulation to promote tumor growth while potentiating immunotherapy responses.
肥胖相关癌症对免疫检查点阻断的反应增强，但机制尚不清楚。在最近的一期《自然》杂志上，Bader 等人报告称，肥胖小鼠诱导巨噬细胞 PD-1 的上调，以促进肿瘤生长，同时增强免疫治疗反应。
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