Quantitative Assessments of Tumor Activity in a General Oncologic PET/CT Population: Which Metric Minimizes Tracer Uptake Time Dependence?

In oncologic PET, the SUV and standardized uptake ratio (SUR) of a viable tumor generally increase during the postinjection period. In contrast, the net influx rate ( ), which is derived from dynamic PET data, should remain relatively constant. Uptake-time-corrected SUV (cSUV) and SUR (cSUR) have been proposed as uptake-time-independent, static alternatives to Our primary aim was to quantify the intrascan repeatability of , SUV, cSUV, SUR, and cSUR among malignant lesions on PET/CT. An exploratory aim was to assess the ability of cSUR to estimate This prospective, single-center study enrolled adults undergoing standard-of-care oncologic PET/CT. SUV and images were reconstructed from dynamic PET data obtained before (∼35-50 min after injection) and after (∼75-90 min after injection) standard-of-care imaging. Tumors were manually segmented. Quantitative metrics were extracted. cSUVs and cSURs were calculated for a 60-min postinjection reference uptake time. The magnitude of the intrascan test-retest percent change (test-retest |%Δ|) was calculated. Coefficients of determination ( ) and intraclass correlation coefficients (ICC) were also computed. Differences between metrics were assessed via the Wilcoxon signed-rank test (α, 0.05). This study enrolled 78 subjects; 41 subjects (mean age, 63.8 y; 24 men) with 116 lesions were analyzed. For both tracers, SUV and maximum SUR (SUR) had large early-to-late increases (i.e., poor intrascan repeatability). Among [F]FDG-avid lesions ( = 93), there were no differences in intrascan repeatability (median test-retest |%Δ|; ICC) between the maximum ( ) (13%; 0.97) and either the maximum cSUV (cSUV) (12%, = 0.90; 0.96) or the maximum cSUR (cSUR) (13%, = 0.67; 0.94). For DOTATATE-avid lesions ( = 23), there were no differences in intrascan repeatability between the (11%; 0.98) and either the cSUV (13%, = 0.41; 0.98) or the cSUR (11%, = 0.08; 0.94). The SUV, cSUV, SUR, and cSUR were all strongly correlated with the for both [F]FDG ( , 0.81-0.92) and DOTATATE ( , 0.88-0.96), but the cSUR provided the best agreement with the across early-to-late time points for [F]FDG (ICC, 0.69-0.75) and DOTATATE (ICC, 0.90-0.91). , cSUV, and cSUR had low uptake time dependence compared with SUV and SUR The can be predicted from cSUR.