Nunzi Emilia, Pariano Marilena, Costantini Claudio, Garaci Enrico, Puccetti Paolo, Romani Luigina
Department of Medicine and Surgery, University of Perugia, Perugia, Italy.
Casa di cura San Raffaele, Sulmona, L'Aquila, Italy.
Trends Endocrinol Metab. 2025 Jan;36(1):83-95. doi: 10.1016/j.tem.2024.07.014. Epub 2024 Aug 13.
As a result of a long evolutionary history, serotonin plays a variety of physiological roles, including neurological, cardiovascular, gastrointestinal, and endocrine functions. While many of these activities can be accommodated within the serotoninergic activity, recent findings have revealed an unsuspected role of serotonin in orchestrating host and microbial dialogue at the tryptophan dining table, to the benefit of local and systemic homeostasis. Herein we review the dual role of serotonin at the host-microbe interface and discuss how unraveling the interconnections among the host and microbial pathways of tryptophan degradation may help to accommodate the versatility of serotonin in physiology and pathology.
由于漫长的进化史，血清素发挥着多种生理作用，包括神经、心血管、胃肠道和内分泌功能。虽然这些活动中的许多都可以在血清素能活动范围内得到解释，但最近的研究结果揭示了血清素在色氨酸“餐桌”上协调宿主与微生物对话方面出人意料的作用，这有利于局部和全身的体内平衡。在此，我们综述血清素在宿主-微生物界面的双重作用，并讨论阐明宿主和微生物色氨酸降解途径之间的相互联系如何有助于适应血清素在生理和病理中的多功能性。
