Hou Xiaohong, Chen Yue, Chen Fengming, Yin Yulong, Xu Kang
Hunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic Process, National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha, China.
College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, China.
Anim Biosci. 2025 Sep;38(9):1827-1840. doi: 10.5713/ab.25.0100. Epub 2025 May 19.
Numerous commensal microbes colonize in the pig gut, while the microbiota gets benefits from the gut environment, it additionally assists significantly with the host's development, metabolism, and immunity. The immune system can regulate the homeostasis of gut microorganisms by secreting a variety of effector factors. Similarly, gut microorganisms can also regulate the intestinal immune system via specific components or metabolites. Despite their close relationship, microbes and immune cells have their own individual ecological niche in the gut. Microbes are confined to the intestinal lumen, while immune cells are located in the intestinal tissues, and the mechanisms of how they interact with each other to promote intestinal health have not yet been thoroughly investigated. This article focuses on the different mechanisms by the interaction between intestinal immune system, gut microorganisms and microbial metabolites to regulate the intestinal health of piglets, and discusses the strategies to enhance the intestinal health of piglets through dietary interventions in order to provide theoretical support promoting the healthy growth of piglets.
许多共生微生物定殖于猪的肠道中，微生物群从肠道环境中获取益处的同时，还对宿主的发育、代谢和免疫有显著的辅助作用。免疫系统可通过分泌多种效应因子来调节肠道微生物的稳态。同样，肠道微生物也可通过特定成分或代谢产物来调节肠道免疫系统。尽管微生物与免疫细胞关系密切，但它们在肠道中拥有各自独立的生态位。微生物局限于肠腔，而免疫细胞位于肠道组织中，它们相互作用促进肠道健康的机制尚未得到充分研究。本文重点探讨肠道免疫系统、肠道微生物和微生物代谢产物之间相互作用调节仔猪肠道健康的不同机制，并讨论通过饮食干预增强仔猪肠道健康的策略，以期为促进仔猪健康生长提供理论支持。
