Li Jiaxin, Zhu Junyan, Yang Hui, Hou Fajian
Key Laboratory of RNA Science and Engineering, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China.
Department of Neurosurgery, Huashan Hospital, Institute for Translational Brain Research, MOE Frontiers Center for Brain Science, Shanghai Medical College, Fudan University, Shanghai 200032, China.
J Mol Cell Biol. 2024 Dec 20;16(7). doi: 10.1093/jmcb/mjae029.
RNA-sensing pathways play a pivotal role in host defense against pathogenic infections to maintain cellular homeostasis. However, in the absence of infection, certain endogenous RNAs can serve as the activators of RNA-sensing pathways as well. The inappropriate activation of RNA-sensing pathways by self-ligands leads to systemic inflammation and autoimmune diseases. In this review, we summarize current findings on the sterile activation of RNA sensors, as well as its implications in autoimmunity, inflammatory diseases, and therapeutics.
RNA 传感通路在宿主抵御病原体感染以维持细胞内稳态中起关键作用。然而，在没有感染的情况下，某些内源性 RNA 也可作为 RNA 传感通路的激活剂。自身配体对 RNA 传感通路的不当激活会导致全身性炎症和自身免疫性疾病。在这篇综述中，我们总结了关于 RNA 传感器无菌激活的当前研究结果，及其在自身免疫、炎症性疾病和治疗学中的意义。
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