Department of Urology, IRCCS "Regina Elena" National Cancer Institute, Rome, Italy.
Department of Urology, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy.
World J Urol. 2024 Aug 14;42(1):484. doi: 10.1007/s00345-024-05187-8.
To investigate Health Related Quality of Life (HRQoL) features of long survivors after radical cystectomy (RC) compared to healthy population (HP) control.
Patients with cT2-4/N0/M0 or Bacillus Calmette-Guérine (BCG) failure high-grade non-muscle-invasive bladder cancer (NMIBC) undergoing RC and ileal Orthotopic Neobladder (iON) from 2010 to 2015 were enrolled in "BCa cohort". Patients aged ≥ 18 yrs old, with no previous diagnosis of BCa or any genitourinary cancer disease were included from General Practitioner outpatients and enrolled in "HP cohort". A 1:1 propensity score matched (PSM) analysis was performed, and HRQoL outcomes were collected according to European Organization for Research and Treatment of Cancer (EORTC), and generic (QLQ-C30) questionnaires.
A total of 401 patients were enrolled in the study, 99 and 302 in BCa and HP cohorts, respectively. After applying 1:1 PSM analysis 67 patients were included for each group. Analysis of self-reported HRQoL outcomes described a better HRQoL in BCa cohort. Particularly, in the long run patients receiving RC and iON significantly experienced higher global health-status/QoL (p < 0.001), emotional (p = 0.003) and cognitive functioning (p < 0.001) than HP cohort, providing a significantly lower impairment in terms of fatigue (p = 0.004), pain (p = 0.004), dyspnea (p = 0.02) and insomnia (p = 0.005).
Long survivors after RC and iON seems to have a major awareness of self-reported HRQoL compared to HP control group.
研究根治性膀胱切除术（RC）后长期幸存者与健康人群（HP）对照的健康相关生活质量（HRQoL）特征。
从 2010 年至 2015 年，招募了接受 RC 和回肠原位新膀胱（iON）的 cT2-4/N0/M0 或卡介苗（BCG）失败的高级别非肌肉浸润性膀胱癌（NMIBC）患者，并纳入“BCa 队列”。从全科医生门诊招募了年龄≥18 岁、无膀胱癌或任何泌尿生殖系统癌症病史的患者，并纳入“HP 队列”。进行了 1:1 倾向评分匹配（PSM）分析，并根据欧洲癌症研究与治疗组织（EORTC）和通用（QLQ-C30）问卷收集 HRQoL 结果。
共有 401 名患者入组，BCa 和 HP 队列分别为 99 名和 302 名。在应用 1:1 PSM 分析后，每组纳入 67 名患者。自我报告的 HRQoL 结果分析表明，BCa 队列的 HRQoL 更好。特别是，从长远来看，接受 RC 和 iON 的患者在总体健康状况/生活质量（p<0.001）、情绪（p=0.003）和认知功能（p<0.001）方面显著优于 HP 队列，在疲劳（p=0.004）、疼痛（p=0.004）、呼吸困难（p=0.02）和失眠（p=0.005）方面的损伤显著较低。
与 HP 对照组相比，RC 和 iON 后长期幸存者似乎对自我报告的 HRQoL 有更深刻的认识。
