Department of Radiological Sciences, University of California, Irvine, Irvine, CA, 92697, USA.
Eur Radiol Exp. 2024 Aug 14;8(1):91. doi: 10.1186/s41747-024-00498-2.
We prospectively assessed the reproducibility of a novel low-dose single-volume dynamic computed tomography (CT) myocardial blood flow measurement technique.
Thirty-four pairs of measurements were made under rest and stress conditions in 13 swine (54.3 ± 12.3 kg). One or two acquisition pairs were acquired in each animal with a 10-min delay between each pair. Contrast (370 mgI/mL; 0.5 mL/kg) and a diluted contrast/saline chaser (0.5 mL/kg; 30:70 contrast/saline) were injected peripherally at 5 mL/s, followed by bolus tracking and acquisition of a single volume scan (100 kVp; 200 mA) with a 320-slice CT scanner. Bolus tracking and single volume scan data were used to derive perfusion in mL/min/g using a first-pass analysis model; the coronary perfusion territories of the left anterior descending (LAD), left circumflex (LCx), and right coronary artery (RCA) were automatically assigned using a previously validated minimum-cost path technique. The reproducibility of CT myocardial perfusion measurement within the LAD, LCx, RCA, and the whole myocardium was assessed via regression analysis. The average CT dose index (CTDI) of perfusion measurement was recorded.
The repeated first (P) and second (P) single-volume CT perfusion measurements were related by P = 1.01P - 0.03(ρ = 0.96; RMSE = 0.08 mL/min/g; RMSE = 0.07 mL/min/g) for the whole myocardium, and by P = 0.86P + 0.13(ρ = 0.87; RMSE = 0.31 mL/min/g; RMSE = 0.29 mL/min/g) for the LAD, LCx, and RCA perfusion territories. The average CTDI of the single-volume CT perfusion measurement was 10.5 mGy.
The single-volume CT blood flow measurement technique provides reproducible low-dose myocardial perfusion measurement using only bolus tracking data and a single whole-heart volume scan.
The single-volume CT blood flow measurement technique is a noninvasive tool that reproducibly measures myocardial perfusion and provides coronary CT angiograms, allowing for simultaneous anatomic-physiologic assessment of myocardial ischemia.
A low-dose single-volume dynamic CT myocardial blood flow measurement technique is reproducible. Motion misregistration artifacts are eliminated using a single-volume CT perfusion technique. This technique enables combined anatomic-physiologic assessment of coronary artery disease.
我们前瞻性评估了一种新型低剂量单容积动态 CT 心肌血流测量技术的可重复性。
在 13 头猪（54.3±12.3kg）中，在休息和应激条件下进行了 34 对测量。在每对之间有 10 分钟的延迟，每个动物中采集一对或两对。外周注射造影剂（370mgI/mL；0.5mL/kg）和稀释的造影剂/盐水追踪剂（0.5mL/kg；30:70 造影剂/盐水），以 5mL/s 的速度注射，然后进行团注跟踪并使用 320 层 CT 扫描仪采集单容积扫描（100kVp；200mA）。使用首过分析模型从团注跟踪和单容积扫描数据中得出 mL/min/g 的灌注量；使用经过验证的最小成本路径技术自动分配左前降支（LAD）、左旋支（LCx）和右冠状动脉（RCA）的冠状动脉灌注区域。通过回归分析评估 LAD、LCx、RCA 和整个心肌内 CT 心肌灌注测量的重复性。记录平均 CT 剂量指数（CTDI）的灌注测量。
重复的第一次（P）和第二次（P）单容积 CT 灌注测量之间的关系为 P = 1.01P - 0.03（ρ = 0.96；RMSE = 0.08mL/min/g；RMSE = 0.07mL/min/g），适用于整个心肌，而对于 LAD、LCx 和 RCA 灌注区域，P = 0.86P + 0.13（ρ = 0.87；RMSE = 0.31mL/min/g；RMSE = 0.29mL/min/g）。单容积 CT 灌注测量的平均 CTDI 为 10.5mGy。
单容积 CT 血流测量技术仅使用团注跟踪数据和单个全心容积扫描即可提供可重复的低剂量心肌灌注测量。
单容积 CT 血流测量技术是一种非侵入性工具，可重复性地测量心肌灌注，并提供冠状动脉 CT 血管造影，从而实现心肌缺血的解剖-生理同时评估。
低剂量单容积动态 CT 心肌血流测量技术具有可重复性。使用单容积 CT 灌注技术消除了运动配准伪影。该技术能够同时进行冠状动脉疾病的解剖-生理评估。
