Department of Physiology and Biophysics, Mississippi Center for Heart Research, University of Mississippi Medical Center, Jackson, Mississippi, USA.
G.V. (Sonny) Montgomery VA Medical Center, Jackson, Mississippi, USA.
FASEB J. 2024 Aug 31;38(16):e23890. doi: 10.1096/fj.202401128R.
Thromboinflammation is a complex pathology associated with inflammation and coagulation. In cases of cardiovascular disease, in particular ischemia-reperfusion injury, thromboinflammation is a common complication. Increased understanding of thromboinflammation depends on an improved concept of the mechanisms of cells and proteins at the axis of coagulation and inflammation. Among these elements are activated protein C and platelets. This review summarizes the complex interactions of activated protein C and platelets regulating thromboinflammation in cardiovascular disease. By unraveling the pathways of platelets and APC in the inflammatory and coagulation cascades, this review summarizes the role of these vital mediators in the development and perpetuation of heart disease and the thromboinflammation-driven complications of cardiovascular disease. Furthermore, this review emphasizes the significance of the counteracting effects of platelets and APC and their combined role in disease states.
血栓炎症是一种与炎症和凝血相关的复杂病理。在心血管疾病的情况下，特别是缺血再灌注损伤，血栓炎症是一种常见的并发症。对血栓炎症的理解增加取决于对凝血和炎症轴上细胞和蛋白质机制的改善概念。这些元素包括活化蛋白 C 和血小板。这篇综述总结了活化蛋白 C 和血小板调节心血管疾病中血栓炎症的复杂相互作用。通过揭示血小板和 APC 在炎症和凝血级联中的途径，本综述总结了这些重要介质在心脏病发展和持续以及心血管疾病血栓炎症驱动的并发症中的作用。此外，本综述强调了血小板和 APC 的拮抗作用的重要性及其在疾病状态下的共同作用。
