Department of Clinical Laboratory, Eye and ENT Hospital of Fudan University, Shanghai, China.
Department of Ophthalmology, Eye and ENT Hospital of Fudan University, Shanghai, China.
Curr Eye Res. 2024 Nov;49(11):1180-1183. doi: 10.1080/02713683.2024.2374840. Epub 2024 Aug 14.
To explore the expression of matrix metalloproteinase-3 (MMP-3) in the aqueous humor of patients with Posner-Schlossman syndrome (PSS), and the association between MMP-3 and PSS.
Peripheral blood and aqueous humor were routinely collected from 29 patients with PSS (PSS group) and 30 patients with age-related-cataract (ARC) (control group). The content of MMP-3 in serum and aqueous humor was measured by immunoturbidimetry. The correlation between MMP-3 and ophthalmic examination results were verified by Spearman's correlation analysis.
The MMP-3 level in the aqueous humor of the PSS group was (25.86 ± 13.4)ng/ml, significantly higher than that in the control group (3.9 ± 2.7)ng/ml( < 0.001), while there was no significant difference in serum MMP-3 level between the two groups ( = 0.125). The endothelial cell density (ECD) in the aqueous humor of the PSS group was (2078 ± 440) cell/mm, intraocular pressure (IOP) in the aqueous humor of the PSS group was (33 ± 12) mmHg. The correlation analysis of aqueous humor MMP-3 and various ophthalmic examination results showed that aqueous humor MMP-3 had a moderate correlation with IOP and the difference in ECD between the affected eye and the fellow eye.
MMP-3 level is elevated in the aqueous humor of PSS patients, and it may play an important role in the pathogenesis of PSS.
探讨基质金属蛋白酶-3（MMP-3）在 Posner-Schlossman 综合征（PSS）患者房水中的表达及其与 PSS 的关系。
常规收集 29 例 PSS 患者（PSS 组）和 30 例年龄相关性白内障（ARC）患者（对照组）的外周血和房水。采用免疫比浊法检测血清和房水中 MMP-3 的含量。通过 Spearman 相关分析验证 MMP-3 与眼科检查结果的相关性。
PSS 组房水中 MMP-3 水平为（25.86±13.4）ng/ml，明显高于对照组（3.9±2.7）ng/ml（<0.001），而两组血清 MMP-3 水平无差异（=0.125）。PSS 组房水中的内皮细胞密度（ECD）为（2078±440）个/mm，房水中的眼内压（IOP）为（33±12）mmHg。房水中 MMP-3 与各种眼科检查结果的相关性分析表明，房水中 MMP-3 与 IOP 及患眼与对侧眼 ECD 差异呈中度相关。
PSS 患者房水中 MMP-3 水平升高，可能在 PSS 的发病机制中起重要作用。
