Guo L W, Zheng L Y, Chen Q, Liu Y, Xu H F, Kang R H, Wang H, Wang X Y, Liu S Z, Zhang S K
Henan Office for Cancer Control and Research, Henan Engineering Research Center of Cancer Prevention and Control, Henan International Joint Laboratory of Cancer Prevention, the Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou 450008, China.
Zhonghua Zhong Liu Za Zhi. 2024 Aug 23;46(8):794-800. doi: 10.3760/cma.j.cn112152-20231026-00272.
To analyze the detection of colorectal advanced neoplasms in the population who underwent colonoscopy screening in Henan Province as part of the Urban China Cancer Screening Program and its influencing factors. A cross-sectional study design was employed. Based on the Cancer Screening Program conducted in Henan Province, the study enrolled 7 454 urban residents who manifested no symptoms and were recruited from eight cities in the province, including Zhengzhou, Zhumadian, Anyang, Luoyang, Nanyang, Jiaozuo, Xinxiang, and Puyang from October 2013 to October 2019, and participated in colonoscopy screening. The χ test was used to compare the detection rates of colorectal advanced neoplasms among participants with different characteristics, and a multivariate logistic stepwise regression model was used to analyze the factors affecting the detection rates. A total of 7 454 subjects underwent colonoscopy screening, and 112 cases of colorectal advanced neoplasms were detected. Multivariate logistic regression analysis suggested that older age, smoking, higher meat intake, history of diabetes, and family history of colorectal cancer in a first-degree relative were risk factors for colorectal advanced neoplasms. The detection rate was significantly higher in people aged 60-74 years compared with those aged 40-49 years, with an odds ratio () of 2.04 (95% : 1.23-3.38).The rates were higher in people who smoked than those who did not smoke, with an of 2.21 (95% : 1.48-3.31), and in people who consumed more meat than those who consumed less, with an of 1.53 (95% : 1.04-2.26). Those with diabetes had a higher detection rate compared with those without, with an of 1.69 (95% : 1.07-2.69), and those with a first-degree family history of colorectal cancer had a higher detection rate than those without, with an of 1.64 (95% : 1.09-2.46). The detection rate of colorectal advanced neoplasms through colonoscopy screening in Henan Province covered by the Urban China Cancer Screening Program is 1.50%. Older age, smoking, higher meat intake, history of diabetes, and family history of colorectal cancer in a first-degree relative are identified as risk factors for colorectal advanced neoplasms.
分析作为中国城市癌症筛查项目一部分在河南省接受结肠镜筛查人群中结直肠高级别肿瘤的检出情况及其影响因素。采用横断面研究设计。基于河南省开展的癌症筛查项目，本研究纳入了2013年10月至2019年10月期间从该省八个城市（包括郑州、驻马店、安阳、洛阳、南阳、焦作、新乡和濮阳）招募的7454名无症状城市居民，他们均参加了结肠镜筛查。采用χ检验比较不同特征参与者中结直肠高级别肿瘤的检出率，并使用多因素logistic逐步回归模型分析影响检出率的因素。共有7454名受试者接受了结肠镜筛查，检出112例结直肠高级别肿瘤。多因素logistic回归分析表明，年龄较大、吸烟、肉类摄入量较高、有糖尿病史以及一级亲属有结直肠癌家族史是结直肠高级别肿瘤的危险因素。60 - 74岁人群的检出率显著高于40 - 49岁人群，比值比（OR）为2.04（95%可信区间：1.23 - 3.38）。吸烟者的检出率高于不吸烟者，OR为2.21（95%可信区间：1.48 - 3.31），肉类摄入量多的人高于摄入量少的人，OR为1.53（95%可信区间：1.04 - 2.26）。有糖尿病者的检出率高于无糖尿病者，OR为1.69（95%可信区间：1.07 - 2.69），有结直肠癌一级家族史者的检出率高于无家族史者，OR为1.64（95%可信区间：1.09 - 2.46）。在中国城市癌症筛查项目覆盖的河南省，通过结肠镜筛查结直肠高级别肿瘤的检出率为1.50%。年龄较大、吸烟、肉类摄入量较高、有糖尿病史以及一级亲属有结直肠癌家族史被确定为结直肠高级别肿瘤的危险因素。
