Wojtera Bartosz, Ostrowska Kamila, Szewczyk Mateusz, Masternak Michał M, Golusiński Wojciech
Department of Head and Neck Surgery, Greater Poland Cancer Centre, Poznan University of Medical Sciences, Poznan, Poland.
Radiobiology Laboratory, Department of Medical Physics, Greater Poland Cancer Centre, Poznan University of Medical Sciences, Poznan, Poland.
Rep Pract Oncol Radiother. 2024 Jun 6;29(2):258-270. doi: 10.5603/rpor.99674. eCollection 2024.
The chloride intracellular channels (CLICs) family includes six ion channels (CLIC1-CLIC6) expressed on the cellular level and secreted into interstitial fluid and blood. They are involved in the physiological functioning of multiple systems as well as the pathogenetic processes of cancer. CLICs play essential roles in the tumor microenvironment. The current systematic review aimed at identifying and summarizing the research of CLICs in oncology on clinical material to assess CLICs' potential as novel biomarkers and personalized therapy targets.
The authors systematically searched the PubMed database for original articles concerning CLIC research on clinical material of all types of cancer - fluids and tissues.
Fifty-three articles investigating in summary 3944 clinical samples were qualified for the current review. Studied material included 3438 tumor samples (87%), 437 blood samples (11%), and 69 interstitial fluid samples (2%). Studies investigated 21 cancer types, mostly hepatocellular carcinoma, colorectal, ovarian, and gastric cancer. Importantly, CLIC1, CLIC2, CLIC3, CLIC4, and CLIC5 were differently expressed in cancerous tissues and patients' blood compared to healthy controls. Moreover, CLICs were found to be involved in several cancer-associated signaling pathways, such as PI3K/AKT, MAPK/ERK, and MAPK/p38.
CLIC family members may be candidates for potential novel cancer biomarkers due to the contrast in their expression between cancerous and healthy tissues and secretion to the interstitial fluid and blood. CLICs are investigated as potential therapeutic targets because of their involvement in cancer pathogenesis and tumor microenvironment.
氯离子细胞内通道（CLICs）家族包括六个离子通道（CLIC1 - CLIC6），它们在细胞水平上表达，并分泌到组织液和血液中。它们参与多个系统的生理功能以及癌症的发病过程。CLICs在肿瘤微环境中发挥着重要作用。当前的系统评价旨在识别和总结关于CLICs在肿瘤学临床材料方面的研究，以评估CLICs作为新型生物标志物和个性化治疗靶点的潜力。
作者系统检索了PubMed数据库，以查找有关各类癌症（体液和组织）临床材料中CLIC研究的原始文章。
共有53篇文章对总计3944份临床样本进行了研究，符合本次综述的要求。研究材料包括3438份肿瘤样本（87%）、437份血液样本（11%）和69份组织液样本（2%）。研究涉及21种癌症类型，主要是肝细胞癌、结直肠癌、卵巢癌和胃癌。重要的是，与健康对照相比，CLIC1、CLIC2、CLIC3、CLIC4和CLIC5在癌组织和患者血液中的表达存在差异。此外，发现CLICs参与了多种与癌症相关的信号通路，如PI3K/AKT、MAPK/ERK和MAPK/p38。
由于CLIC家族成员在癌组织与健康组织中的表达差异以及向组织液和血液中的分泌情况，它们可能是潜在的新型癌症生物标志物。由于CLICs参与癌症发病机制和肿瘤微环境，因此它们被作为潜在的治疗靶点进行研究。
