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头颈部鳞状细胞癌中的微小RNA：个性化肿瘤学前景光明但仍任重道远

miRNA in head and neck squamous cell carcinomas: promising but still distant future of personalized oncology.

作者信息

Kozłowska-Masłoń Joanna, Guglas Kacper, Kolenda Tomasz, Lamperska Katarzyna, Makałowska Izabela

机构信息

Laboratory of Cancer Genetics, Greater oland Cancer Centre, Poznan, Poland.

Institute of Human Biology and Evolution, Faculty of Biology, Adam Mickiewicz University, Poznan, Poland.

出版信息

Rep Pract Oncol Radiother. 2023 Nov 16;28(5):681-697. doi: 10.5603/rpor.96666. eCollection 2023.

DOI:10.5603/rpor.96666
PMID:38179293
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10764040/
Abstract

Head and neck squamous cell carcinoma is one of the most common and fatal cancers worldwide. Lack of appropriate preventive screening tests, late detection, and high heterogeneity of these tumors are the main reasons for the unsatisfactory effects of therapy and, consequently, unfavorable outcomes for patients. An opportunity to improve the quality of diagnostics and treatment of this group of cancers are microRNAs (miRNAs) - molecules with a great potential both as biomarkers and therapeutic targets. This review aims to present the characteristics of these short non-coding RNAs (ncRNAs) and summarize the current reports on their use in oncology focused on medical strategies tailored to patients' needs.

摘要

头颈部鳞状细胞癌是全球最常见且致命的癌症之一。缺乏适当的预防性筛查测试、检测延迟以及这些肿瘤的高度异质性是治疗效果不尽人意的主要原因，进而导致患者预后不佳。微小RNA（miRNA）为改善这类癌症的诊断和治疗质量带来了契机，miRNA作为生物标志物和治疗靶点都具有巨大潜力。本综述旨在介绍这些短链非编码RNA（ncRNA）的特征，并总结当前有关其在肿瘤学中的应用的报告，重点关注针对患者需求定制的医学策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/82e3/10764040/05777007bc73/rpor-28-5-681f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/82e3/10764040/85e40de47dba/rpor-28-5-681f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/82e3/10764040/05777007bc73/rpor-28-5-681f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/82e3/10764040/85e40de47dba/rpor-28-5-681f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/82e3/10764040/05777007bc73/rpor-28-5-681f2.jpg

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