Deng Hao, Cao Hongwei, Wang Yanjin, Li Jiaqi, Dai Jingwen, Li Lian-Feng, Qiu Hua-Ji, Li Su
State Key Laboratory for Animal Disease Control and Prevention, National African Swine Fever Para-reference Laboratory, National High Containment Facilities for Animal Diseases Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China.
Front Microbiol. 2024 Jul 31;15:1450060. doi: 10.3389/fmicb.2024.1450060. eCollection 2024.
Viral infections usually induce the rearrangement of cellular cytoskeletal proteins and organelle membrane structures, thus creating independent compartments [termed replication organelles (ROs)] to facilitate viral genome replication. Within the ROs, viral replicases, including polymerases, helicases, and ligases, play functional roles during viral replication. These viral replicases are pivotal in the virus life cycle, and numerous studies have demonstrated that the viral replicases could be the potential targets for drugs development. Here, we summarize primarily the key replicases within viral ROs and emphasize the advancements of antiviral drugs targeting crucial viral replicases, providing novel insights into the future development of antiviral strategies.
病毒感染通常会诱导细胞细胞骨架蛋白和细胞器膜结构的重排，从而形成独立的区室（称为复制区室，ROs）以促进病毒基因组复制。在ROs内，病毒复制酶，包括聚合酶、解旋酶和连接酶，在病毒复制过程中发挥功能作用。这些病毒复制酶在病毒生命周期中至关重要，并且大量研究表明病毒复制酶可能是药物开发的潜在靶点。在此，我们主要总结病毒ROs内的关键复制酶，并强调针对关键病毒复制酶的抗病毒药物的进展，为抗病毒策略的未来发展提供新见解。
