Zeng Xiaoyan, Tong Li
Qinghai University, Xining, China.
Qinghai Provincial Key Laboratory of Traditional Chinese Medicine Research for Glucolipid Metabolic Diseases, Xining, China.
Front Med (Lausanne). 2024 Jul 31;11:1422267. doi: 10.3389/fmed.2024.1422267. eCollection 2024.
Studies based on observations have indicated potential associations between chronic gastrointestinal diseases and an increased risk of erectile dysfunction (ED). However, the causality of these connections remains ambiguous.
Summary data for chronic gastrointestinal diseases were extracted from public data. Summary data on ED were extracted from three distinct sources. The genetic correlations between chronic gastrointestinal diseases and ED were explored using linkage disequilibrium score regression (LDSC). The causal associations between chronic gastrointestinal diseases and ED were evaluated using Mendelian randomization (MR) analysis, followed by a meta-analysis to determine the ultimate causal effect.
The LDSC results suggested significant genetic correlations between Crohn's disease (CD) and ED. Inflammatory bowel disease (IBD), ulcerative colitis (UC), and liver cirrhosis (LC) were found to have potential genetic correlations with ED. The combined multiple MR results indicate that IBD and CD have significant causal relationships with ED, while colorectal cancer (CRC) may have a potential causal effect on ED.
This research provided evidence supporting a causal association between IBD, CD, CRC, and ED. The impact of chronic gastrointestinal diseases on ED warrants greater attention in clinical practice.
基于观察性的研究表明，慢性胃肠疾病与勃起功能障碍（ED）风险增加之间存在潜在关联。然而，这些联系的因果关系仍不明确。
从公开数据中提取慢性胃肠疾病的汇总数据。从三个不同来源提取ED的汇总数据。使用连锁不平衡评分回归（LDSC）探索慢性胃肠疾病与ED之间的遗传相关性。使用孟德尔随机化（MR）分析评估慢性胃肠疾病与ED之间的因果关联，随后进行荟萃分析以确定最终的因果效应。
LDSC结果表明克罗恩病（CD）与ED之间存在显著的遗传相关性。发现炎症性肠病（IBD）、溃疡性结肠炎（UC）和肝硬化（LC）与ED存在潜在的遗传相关性。综合多个MR结果表明，IBD和CD与ED存在显著的因果关系，而结直肠癌（CRC）可能对ED有潜在的因果影响。
本研究提供了证据支持IBD、CD、CRC与ED之间的因果关联。慢性胃肠疾病对ED的影响在临床实践中值得更多关注。
