Chen Di, Zhou Chao, Luo Quanhai, Chen Changsheng, Liu Gang
Department of Urology, The Frist Affiliated Hospital of Guangxi Medical University, Nanning, China.
Department of Assisted Reproduction, Nanxishan Hospital of Guangxi Zhuang Autonomous Region, Guilin, China.
Sci Rep. 2024 Jan 25;14(1):2137. doi: 10.1038/s41598-024-52712-1.
This study aimed to evaluate the causal effects of inflammatory bowel disease (IBD) and erectile dysfunction (ED) using Mendelian randomization (MR). All datasets were obtained from the public genome-wide association study database. In the exposure group, 12,882 IBD patients and 21,770 controls were included. A total of 1154 ED patients and 94,024 controls were included in the outcome group. Two-sample MR was conducted to estimate the causal effect of IBD on ED. Furthermore, Crohn's disease (CD) and ulcerative colitis (UC) were exposure factors in subgroup analyses. Weighted median, MR-egger, Inverse-variant weighted (IVW), weighted mode, and simple mode methods were used in MR analysis. Horizontal pleiotropy test, heterogeneity test, and leave-one-out method were utilized to evaluate the sensitivity and stability of results. After analysis, 62, 52, and 36 single nucleotide polymorphisms (SNPs) that IBD-ED, CD-ED, and UC-ED were included, respectively. The incidence of ED was increased by IBD (IVW: OR = 1.110, 95% CI = 1.017-1.211, P = 0.019; P-heterogeneity > 0.05) and, in addition, ED was affected by CD (IVW: OR = 1.085, 95% CI = 1.015-1.160, P = 0.016; P-heterogeneity > 0.05). However, there was no causal effect of UC on ED (IVW: OR = 1.018, 95% CI = 0.917-1.129, P = 0.743; P-heterogeneity < 0.05). All SNPs showed no significant horizontal pleiotropy (P > 0.05). These results indicate that IBD and CD can cause ED; However, UC did not cause ED. Additional research was required to determine causality and potential mechanisms further.
本研究旨在利用孟德尔随机化（MR）评估炎症性肠病（IBD）与勃起功能障碍（ED）之间的因果关系。所有数据集均来自公开的全基因组关联研究数据库。在暴露组中，纳入了12882例IBD患者和21770例对照。结果组共纳入1154例ED患者和94024例对照。采用两样本MR来估计IBD对ED的因果效应。此外，在亚组分析中，克罗恩病（CD）和溃疡性结肠炎（UC）为暴露因素。MR分析采用加权中位数、MR-egger、逆方差加权（IVW）、加权模式和简单模式方法。利用水平多效性检验、异质性检验和留一法来评估结果的敏感性和稳定性。分析后，分别纳入了62个、52个和36个IBD-ED、CD-ED和UC-ED的单核苷酸多态性（SNP）。IBD使ED的发病率增加（IVW：OR = 1.110，95%CI = 1.017 - 1.211，P = 0.019；P-异质性>0.05），此外，ED受CD影响（IVW：OR = 1.085，95%CI = 1.015 - 1.160，P = 0.016；P-异质性>0.05）。然而，UC对ED没有因果效应（IVW：OR = 1.018，95%CI = 0.917 - 1.129，P = 0.743；P-异质性<0.05）。所有SNP均未显示出显著的水平多效性（P>0.05）。这些结果表明，IBD和CD可导致ED；然而，UC不会导致ED。需要进一步的研究来确定因果关系和潜在机制。
