颅内动脉钙化的半定量评估与全脑小血管疾病负担评分之间的关联：一项回顾性病例对照研究。
Associations between semi-quantitative evaluation of intracranial arterial calcification and total cerebral small vessel disease burden score: a retrospective case-control study.
作者信息
Chen Peng, Liu Tiejun, Wei Yin, Ma Zhen, Lu Tao, Lan Suxi, Xie Jinling, Mo Shen
机构信息
Department of Radiology, Guangxi International Zhuang Medicine Hospital, Nanning, China.
Department of Ultrasound, Guangxi International Zhuang Medicine Hospital, Nanning, China.
出版信息
Front Neurol. 2024 Jul 31;15:1417186. doi: 10.3389/fneur.2024.1417186. eCollection 2024.
BACKGROUND AND PURPOSE
Arteriosclerotic cerebral small vessel disease (aCSVD) is a cause of cognitive impairment, dementia, and stroke. Developing a better understanding of the risk factor of aCSVD is key to reducing the incidence of these conditions. This study investigated the association between intracranial arterial calcification (IAC) and total cerebral small vessel disease (CSVD) burden score.
MATERIALS AND METHODS
This is a retrospective study, the subjects were transient ischemic attack (TIA) or acute ischemic stroke (AIS) patients. The data of 303 inpatients admitted to our study hospital between December 2018 and July 2020 were analyzed. Four imaging markers of CSVD (lacunes, white matter hyperintensities, cerebral microbleeds, and enlarged perivascular spaces) were evaluated by magnetic resonance imaging, and a total CSVD burden score was calculated. The experimental group was divided into four subgroups according to total CSVD burden score (1-4 points). Patients without CSVD (0 points) served as the control group. Head computerized tomography (CT) scans were used to assess ICA, using Babiarz's method. The correlations between IAC and single imaging markers of CSVD were determined using Spearman's rank correlation. Binary logic regression analysis and multivariate ordered logic regression analysis were used to determine the associations between IAC and aCSVD.
RESULTS
IAC was positively correlated with total CSVD burden score ( = 0.681), deep white matter hyperintensities ( = 0.539), periventricular white matter hyperintensities ( = 0.570), cerebral microbleeds ( = 0.479), lacunes ( = 0.541), and enlarged perivascular spaces ( = 0.554) (all < 0.001). After adjusting for the confounding factors of age, diabetes, and hypertension, aCSVD was independently associated with IAC grade 1-2 [odds ratio (OR) = 23.747, 95% confidence interval (CI) = 8.376-67.327] and IAC grade 3-4 (OR = 30.166, 95% CI = 8.295-109.701). aCSVD severity was independently associated with IAC grade 3-4 (OR = 4.697, 95% CI = 1.349-16.346).
CONCLUSION
IAC is associated with the total CSVD burden score and single imaging signs.
背景与目的
动脉粥样硬化性脑小血管病（aCSVD）是认知障碍、痴呆和中风的一个病因。更好地了解aCSVD的危险因素是降低这些疾病发病率的关键。本研究调查了颅内动脉钙化（IAC）与全脑小血管病（CSVD）负担评分之间的关联。
材料与方法
这是一项回顾性研究，研究对象为短暂性脑缺血发作（TIA）或急性缺血性中风（AIS）患者。分析了2018年12月至2020年7月期间在我院住院的303例患者的数据。通过磁共振成像评估CSVD的四种影像学标志物（腔隙、白质高信号、脑微出血和血管周围间隙扩大），并计算CSVD总负担评分。实验组根据CSVD总负担评分（1 - 4分）分为四个亚组。无CSVD（0分）的患者作为对照组。采用Babiarz法，通过头部计算机断层扫描（CT）评估颅内动脉钙化（IAC）。使用Spearman等级相关性分析IAC与CSVD单一影像学标志物之间的相关性。采用二元逻辑回归分析和多变量有序逻辑回归分析确定IAC与aCSVD之间的关联。
结果
IAC与CSVD总负担评分（=0.681）、深部白质高信号（=0.539）、脑室周围白质高信号（=0.570）、脑微出血（=0.479）、腔隙（=0.541）和血管周围间隙扩大（=0.554）呈正相关（均<0.001）。在调整年龄、糖尿病和高血压等混杂因素后，aCSVD与IAC 1 - 2级独立相关[比值比（OR）=23.747，95%置信区间（CI）=8.376 - 67.327]和IAC 3 - 4级（OR = 30.166，95% CI = 8.295 - 109.701）。aCSVD严重程度与IAC 3 - 4级独立相关（OR = 4.697，95% CI = 1.349 - 16.346）。
结论
IAC与CSVD总负担评分及单一影像学征象相关。
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