Langguth Berthold, Reineke Thorsten, Burkart Martin, Kostev Karel
Department of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany.
Research & Development, Dr. Willmar Schwabe GmbH & Co. KG, Karlsruhe, Germany.
Front Neurol. 2024 Jul 31;15:1402978. doi: 10.3389/fneur.2024.1402978. eCollection 2024.
We aimed to evaluate the drug utilization of extract (Gbe), systemic corticosteroids (CSs), and pentoxifylline (PTXF) for the treatment of acute tinnitus by analyzing electronic patient health record data. In addition, we assessed whether the different drug treatments were associated with different frequencies of repeat visits to ear, nose, and throat (ENT) doctors.
This retrospective cohort study used data from the IQVIA Disease Analyzer (DA) database. It included patients with an initial diagnosis of tinnitus between January 2005 and December 2021, treated by ENT specialists in Germany.
Of 111,629 patients meeting all selection criteria, 51,205 received prescriptions of Gbe, 34,817 of systemic CSs, and 25,607 of PTXF. Gbe prescription was associated with significantly lower odds of a repeat consultation due to tinnitus compared to systemic CSs [odds ratio (OR) 0.91; 95% confidence interval (CI): 0.88-0.95] as well as PTXF (OR 0.74; 95% CI: 0.72-0.77). This association was significant in both men and women and in some age groups.
Gbe is the most frequently ENT specialist-prescribed drug for the treatment of acute tinnitus. It is associated with a reduced likelihood of patients consulting their ENT specialist for tinnitus again compared to systemic CSs and PTXF.
我们旨在通过分析电子患者健康记录数据，评估银杏叶提取物（Gbe）、全身性皮质类固醇（CSs）和己酮可可碱（PTXF）治疗急性耳鸣的药物利用情况。此外，我们评估了不同药物治疗与耳鼻喉（ENT）科医生复诊频率的差异是否相关。
这项回顾性队列研究使用了IQVIA疾病分析器（DA）数据库的数据。研究对象包括2005年1月至2021年12月期间在德国由耳鼻喉科专家诊治的首次诊断为耳鸣的患者。
在111,629名符合所有入选标准的患者中，51,205人接受了Gbe处方，34,817人接受了全身性CSs处方，25,607人接受了PTXF处方。与全身性CSs相比，Gbe处方导致因耳鸣再次就诊的几率显著降低[比值比（OR）0.91；95%置信区间（CI）：0.88 - 0.95]，与PTXF相比也是如此（OR 0.74；95% CI：0.72 - 0.77）。这种关联在男性和女性以及一些年龄组中均显著。
Gbe是耳鼻喉科专家治疗急性耳鸣最常用的处方药。与全身性CSs和PTXF相比，它与患者因耳鸣再次咨询耳鼻喉科专家的可能性降低有关。
