Ear, Nose and Throat Surgery, Lueneburg, Germany.
Neuropsychiatr Dis Treat. 2011;7:441-7. doi: 10.2147/NDT.S22793. Epub 2011 Jul 28.
Tinnitus is a symptom frequently encountered by ear, nose, and throat practitioners. A causal treatment is rarely possible, and drug and nondrug treatment options are limited. One of the frequently prescribed treatments is Ginkgo biloba extract. Therefore, randomized, placebo-controlled clinical trials of Ginkgo biloba extract preparations were searched for and reviewed systematically. There is evidence of efficacy for the standardized extract, EGb 761(®) (Dr Willmar Schwabe GmbH & Co KG Pharmaceuticals, Karlsruhe, Germany), in the treatment of tinnitus from three trials in patients in whom tinnitus was the primary complaint. Supportive evidence comes from a further five trials in patients with age-associated cognitive impairment or dementia in whom tinnitus was present as a concomitant symptom. As yet, the efficacy of other ginkgo preparations has not been proven, which does not necessarily indicate ineffectiveness, but may be due to flawed clinical trials. In conclusion, EGb 761(®), a standardized Ginkgo biloba extract, is an evidence-based treatment option in tinnitus.
耳鸣是耳鼻喉科医生经常遇到的一种症状。很少有因果治疗方法，药物和非药物治疗方法也有限。一种常用的治疗方法是银杏叶提取物。因此，我们系统地搜索并回顾了银杏叶提取物制剂的随机、安慰剂对照临床试验。有证据表明，标准化提取物 EGb 761（®）（德国卡尔斯鲁厄的 Dr Willmar Schwabe GmbH & Co KG 制药公司）在三种以耳鸣为主要主诉的耳鸣患者的治疗中有效。另有五项针对年龄相关性认知障碍或痴呆患者的试验提供了支持性证据，这些患者伴有耳鸣作为伴随症状。到目前为止，其他银杏制剂的疗效尚未得到证实，这并不一定表示无效，但可能是由于临床试验设计缺陷所致。总之，标准化银杏叶提取物 EGb 761（®）是一种基于证据的耳鸣治疗选择。
