Hajizadeh Maryam, Meshksar Aidin, Hassanpour Kiana, Rahmani Saeed, Hooshmandi Sadid, Doozandeh Azadeh, Sharifipour Farideh, Yazdani Shahin, Pakravan Mohammad, Samaeili Azadeh
Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Tehran Province; Department of Ophthalmology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran; Poostchi Ophthalmology Research Center; School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
J Curr Glaucoma Pract. 2024 Apr-Jun;18(2):51-56. doi: 10.5005/jp-journals-10078-1432. Epub 2024 Jul 10.
To compare the outcomes of nonpenetrating deep sclerectomy (NPDS) with and without an expanded polytetrafluoroethylene (e-PTFE) implant combined with phacoemulsification (PE).
Interventional case series with concurrent control group.
Patients with medically uncontrolled glaucoma underwent PE nonpenetrating deep sclerectomy (NPDS) and were consecutively divided into a study group receiving an e-PTFE implant and a control group undergoing PE-NPDS. Intraocular pressure (IOP), corrected distance visual acuity (CDVA), and the number of glaucoma medications at 1 day, 1 week, 1 month, 3 months, and 6 months were recorded.
A total of 22 eyes of 16 patients underwent PE-NPDS, including 11 eyes receiving an e-PTFE implant and another 11 eyes with no implant. NPDS with spacer achieved successful results in all patients, including eight (72.7%) complete and three (27.3%) qualified success, 6 months, postoperatively. The corresponding values in the control group were 10 (90.9%) and 1 (9.1%), respectively. In the spacer group, mean IOP was decreased from 19.3 ± 2.8 at baseline to 12.1 ± 2.0 mm Hg at month 6 ( < 0.001). Corresponding values for the control group were 18.6 ± 3.4 and 10.6 ± 1.5 mm Hg, respectively ( < 0.001). Mean IOPs were comparable between the study groups at all time points. Implant exposure occurred in one of the patients in the study group. While the implant was extruded, the IOP was medically controlled.
Outcomes of PE-NPDS using an e-PTFE implant were comparable to the same surgery without a spacer in the short term. Larger studies with longer follow-ups are needed to determine the efficacy and safety of this new implant.
Hajizadeh M, Meshksar A, Hassanpour K, Expanded Polytetrafluoroethylene Spacer for Nonpenetrating Deep Sclerectomy Combined with Cataract Surgery. J Curr Glaucoma Pract 2024;18(2):51-56.
比较穿透性深层巩膜切除术（NPDS）联合超声乳化术（PE）在植入与未植入膨体聚四氟乙烯（e-PTFE）植入物两种情况下的手术效果。
设有同期对照组的干预性病例系列研究。
药物治疗无法控制眼压的青光眼患者接受PE-NPDS手术，并被连续分为接受e-PTFE植入物的研究组和接受PE-NPDS手术的对照组。记录患者术后1天、1周、1个月、3个月和6个月时的眼压（IOP）、矫正远视力（CDVA）以及青光眼药物使用数量。
16例患者共22只眼接受了PE-NPDS手术，其中11只眼植入了e-PTFE植入物，另外11只眼未植入。植入间隔物的NPDS手术在所有患者中均取得成功，术后6个月时，8例（72.7%）完全成功，3例（27.3%）达到合格成功标准。对照组相应的数值分别为10例（90.9%）和1例（9.1%）。在植入间隔物组中,平均眼压从基线时的19.3±2.8毫米汞柱降至术后6个月时的12.1±2.0毫米汞柱（P<0.001）。对照组相应的数值分别为18.6±3.4和10.6±1.5毫米汞柱（P<0.001）。各时间点两组的平均眼压相当。研究组中有1例患者出现植入物暴露。植入物脱出时，眼压通过药物得到控制。
短期内，使用e-PTFE植入物的PE-NPDS手术效果与未使用间隔物的相同手术相当。需要开展更大规模、随访时间更长的研究来确定这种新型植入物的疗效和安全性。
Hajizadeh M, Meshksar A, Hassanpour K, 膨体聚四氟乙烯间隔物用于穿透性深层巩膜切除术联合白内障手术。《当代青光眼实践杂志》2024;18(2):51-56。
