Ethylene Oxide: An Air Contaminant of Concern.

Ethylene oxide (EtO) is a colorless, flammable, reactive gas commonly used for sterilization and chemical manufacturing. It has become a contaminant of concern for the United States Environmental Protection Agency (USEPA) due to an assessment of its toxicity, which found that EtO is more potent than had been previously understood and which also revised the weight-of-evidence classification of EtO from "probably carcinogenic" to "carcinogenic to humans". With the revised toxicity assessment came findings of increased cancer risk to communities near some facilities that emit EtO to ambient air, including communities with environmental justice (EJ) concerns. To address EtO, the USEPA has conducted intensive research in recent years, centering its attention on measurement and sampling technology development, as well as monitoring of EtO in source emissions, near-source air, and atmospheric environments to further support science-based policy and regulations that reduce harmful impacts to human health. Research efforts by government, academic, and commercial institutions have resulted in the development of novel measurement and monitoring techniques, which has led to more robust characterization of EtO emissions and atmospheric levels across a wide range of concentrations, including trace levels (ppt). This Perspective covers the importance of capturing high quality, analytical measurements of EtO, what is known so far about these measurement technologies, EPA's response to the increasing concerns of EtO contamination, what still needs to be accomplished on the air quality front, and a focus on USEPA research and development moving forward.