Alauddin Waqas, Alam Shahnawaz, Mishra Mohit, Radke Prajakta M, Shree Rishika, Prajesh Brishabh R, Chaturvedi Aparna, Patil Anant, Singh Tarun Kumar, Ahmad Malik Faizan
Physiology, Naraina Medical College and Research Centre, Kanpur, IND.
Physiology, MGM Medical College, Navi Mumbai, IND.
Cureus. 2024 Jul 14;16(7):e64542. doi: 10.7759/cureus.64542. eCollection 2024 Jul.
Ehlers-Danlos syndrome (EDS) may be linked to dysfunction in the autonomic nervous system, affecting collagen production and processing. These collagen abnormalities lead to a condition called dysautonomia. Findings underscore the need for further investigation into autonomic nervous system function in EDS which involves larger studies to strengthen the evidence of non-invasive screening tools like cardiovascular reflex tests. These tests might offer a valuable way to assess an individual's risk for future complications.
This study aimed to assess autonomic reactivity in EDS patients using cardiovascular reflex tests.
This study was conducted at the Department of Physiology, Naraina Medical College and Research Centre, Kanpur (Uttar Pradesh). The cardiovascular reflex test was used to identify 60 individuals, 30 of whom were EDS patients and 30 were healthy controls, with a common age limit of 18-25 years. Cardiovascular reflex tests, such as the delta heart rate, lying-to-standing test (LST), deep breathing test (DBT), and Valsalva maneuver, were performed and recorded for each subject. IBM SPSS Statistics for Windows, Version 21.0 (Released 2012; IBM Corp., Armonk, New York, United States) was used for the compilation and analysis of data.
The expiration-to-inspiration (E:I) ratio and delta heart rate of the EDS patients both significantly decreased as compared to the healthy control group (1.10±0.02 versus 1.22±0.77 and 14.03±0.31 versus 15.52±0.32). The Valsalva ratio of the EDS patients decreased (1.28±0.01) as compared to the healthy control group (1.46±0.01), which was statistically significant. The 30:15 ratio in the EDS patients was significantly decreased compared to the healthy control group (1.08±0.01 versus 1.15±0.01). The handgrip test and cold pressor test results were statistically insignificant.
The study suggests a connection between EDS and autonomic nervous system dysfunction, causing symptoms like tachycardia and hypotension. It recommends exploring non-invasive cardiovascular reflex tests as a tool to identify autonomic dysfunction in EDS patients and predict long-term cardiovascular complications. These tests offer valuable insights into autonomic function.
埃勒斯-当洛综合征（EDS）可能与自主神经系统功能障碍有关，影响胶原蛋白的产生和加工。这些胶原蛋白异常会导致一种称为自主神经功能障碍的病症。研究结果强调有必要进一步研究EDS患者的自主神经系统功能，这需要开展更大规模的研究，以加强诸如心血管反射测试等非侵入性筛查工具的证据。这些测试可能为评估个体未来发生并发症的风险提供一种有价值的方法。
本研究旨在使用心血管反射测试评估EDS患者的自主反应性。
本研究在坎普尔（北方邦）纳拉伊纳医学院和研究中心生理学系进行。采用心血管反射测试对60名个体进行检测，其中30名是EDS患者，30名是健康对照者，年龄范围均为18至25岁。对每个受试者进行心血管反射测试，如心率变化、卧立位试验（LST）、深呼吸试验（DBT）和瓦尔萨尔瓦动作，并进行记录。使用IBM SPSS Statistics for Windows 21.0版本（2012年发布；IBM公司，美国纽约州阿蒙克）对数据进行汇总和分析。
与健康对照组相比，EDS患者的呼气与吸气（E:I）比值和心率变化均显著降低（分别为1.10±0.02对1.22±0.77以及14.03±0.31对15.52±0.32）。与健康对照组（1.46±０.01）相比，EDS患者的瓦尔萨尔瓦比值降低（1.28±0.01），具有统计学意义。与健康对照组相比，EDS患者的30:15比值显著降低（1.08±0.01对1.15±0.01）。握力试验和冷加压试验结果无统计学意义。
该研究表明EDS与自主神经系统功能障碍之间存在关联，可导致心动过速和低血压等症状。建议探索将非侵入性心血管反射测试作为一种工具，用于识别EDS患者的自主神经功能障碍并预测长期心血管并发症。这些测试为自主神经功能提供了有价值的见解。
