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伪装于胃肠道的转移性纯绒毛膜癌

Metastatic Pure Choriocarcinoma Masquerading in the Gastrointestinal Tract.

作者信息

Aujla Parvir, Aleem Abdullah S, Khanna Rohit, Mittal Nitish, Lyons John

机构信息

Internal Medicine, University of Texas Health Science Center at Houston, Houston, USA.

Gastroenterology and Hepatology, Scripps Clinic, La Jolla, USA.

出版信息

Cureus. 2024 Jul 15;16(7):e64566. doi: 10.7759/cureus.64566. eCollection 2024 Jul.

DOI:10.7759/cureus.64566
PMID:39144869
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11323720/
Abstract

This study presents a rare case of pure choriocarcinoma (PCC) with metastasis to the gastrointestinal tract in a 52-year-old male with a history of mixed germ cell tumor in remission. Despite negative oncology surveillance imaging, serum marker monitoring, and a recent colonoscopy, the patient presented with new-onset melena and dysphagia, leading to further diagnostic evaluation. Endoscopic examination revealed an ulcerated duodenal mass, and a computer tomography (CT)-guided liver biopsy confirmed metastatic PCC. This case highlights the aggressive nature of PCC and the importance of considering gastrointestinal metastasis in patients with atypical symptoms, even when in apparent remission.

摘要

本研究报告了一例罕见的纯绒毛膜癌（PCC）病例，该病例发生在一名52岁男性身上，他有混合性生殖细胞肿瘤病史且处于缓解期，目前已发生胃肠道转移。尽管肿瘤学监测影像、血清标志物监测以及近期的结肠镜检查结果均为阴性，但该患者出现了新发的黑便和吞咽困难，从而促使进行进一步的诊断评估。内镜检查发现十二指肠有一个溃疡肿物，计算机断层扫描（CT）引导下的肝脏活检证实为转移性PCC。该病例凸显了PCC的侵袭性，以及对于有非典型症状的患者，即使处于明显缓解期，考虑胃肠道转移的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fff0/11323720/51c9d19e3849/cureus-0016-00000064566-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fff0/11323720/ca58ad8532b1/cureus-0016-00000064566-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fff0/11323720/9397e58863e1/cureus-0016-00000064566-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fff0/11323720/27cae92680f7/cureus-0016-00000064566-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fff0/11323720/51c9d19e3849/cureus-0016-00000064566-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fff0/11323720/ca58ad8532b1/cureus-0016-00000064566-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fff0/11323720/9397e58863e1/cureus-0016-00000064566-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fff0/11323720/27cae92680f7/cureus-0016-00000064566-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fff0/11323720/51c9d19e3849/cureus-0016-00000064566-i04.jpg

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本文引用的文献

1
A poor prognostic male choriocarcinoma with multiple systemic metastases: a case report and the literature review.一例伴有多系统转移的预后不良男性绒毛膜癌：病例报告及文献复习
Front Med (Lausanne). 2024 Mar 20;11:1382672. doi: 10.3389/fmed.2024.1382672. eCollection 2024.
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Pure testicular choriocarcinoma with gastrointestinal metastasis and paraneoplastic symptoms: a case report.纯睾丸绒毛膜癌伴胃肠道转移及副肿瘤症状：病例报告。
BMC Urol. 2023 Jun 3;23(1):102. doi: 10.1186/s12894-023-01271-0.
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Choriocarcinoma with pulmonary and cerebral metastases.伴有肺和脑转移的绒毛膜癌。
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Urology. 2009 Feb;73(2):443.e15-7. doi: 10.1016/j.urology.2008.02.044. Epub 2008 Apr 14.
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Gastrointestinal hemorrhage as first manifestation of metastatic testicular tumor.胃肠道出血作为转移性睾丸肿瘤的首发表现。
Urology. 2005 Dec;66(6):1319. doi: 10.1016/j.urology.2005.06.102.
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European consensus on diagnosis and treatment of germ cell cancer: a report of the European Germ Cell Cancer Consensus Group (EGCCCG).欧洲生殖细胞癌诊断与治疗共识：欧洲生殖细胞癌共识小组（EGCCCG）报告
Ann Oncol. 2004 Sep;15(9):1377-99. doi: 10.1093/annonc/mdh301.
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Gastrointestinal hemorrhage due to metastatic choriocarcinoma with gastric and colonic involvement.转移性绒毛膜癌累及胃和结肠导致的胃肠道出血。
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