Bhatt Shreya, Perez Aleymi, Sarmiento Evan, Alfonso Taylor, Shah Sahil, Hernandez Borges Sergio
Osteopathic Medicine, Nova Southeastern University Dr. Kiran C. Patel College of Osteopathic Medicine, Fort Lauderdale, USA.
Osteopathic Medicine, Lake Erie College of Osteopathic Medicine, Bradenton, USA.
Cureus. 2024 Jul 14;16(7):e64537. doi: 10.7759/cureus.64537. eCollection 2024 Jul.
Acute pancreatitis can be induced by a vast variety of etiologies including its more common causes such as cholelithiasis and alcohol abuse, but in certain cases it can also be secondary to hypertriglyceridemia. Additionally, combined oral contraceptive use can enhance the severity of hypertriglyceridemia-induced acute pancreatitis (HTG-AP). The data between this association is much more limited than the more common causes of acute pancreatitis. In this case, we aim to highlight the onset of hypertriglyceridemia-induced acute pancreatitis due to recent combined oral contraceptive use in a 34-year-old Hispanic female patient with a family history of hypertriglyceridemia. With the initiation of a low-fat diet, insulin regimen, and lipid-lowering medications, she was able to significantly improve her elevated triglyceride levels from 3772 to 440 throughout the duration of her six-day hospital stay. Due to the less commonly known relationship between combined oral contraceptive use and HTG-AP, this case serves to enhance understanding of the pathophysiology of this condition, the appropriate diagnostic evaluation, and the associated treatment options to optimize patient care and create efficacious management plans. By increasing awareness of this association, patients with familial hypertriglyceridemia can be made aware of the risks of combined oral contraceptive use to accordingly prevent complications and improve clinical outcomes.
急性胰腺炎可由多种病因引起，包括其更常见的病因，如胆石症和酒精滥用，但在某些情况下，它也可能继发于高甘油三酯血症。此外，联合使用口服避孕药会加重高甘油三酯血症诱发的急性胰腺炎（HTG-AP）的严重程度。这种关联的数据比急性胰腺炎更常见的病因要有限得多。在本病例中，我们旨在强调一名有高甘油三酯血症家族史的34岁西班牙裔女性患者因近期联合使用口服避孕药而引发高甘油三酯血症诱发的急性胰腺炎。通过开始低脂饮食、胰岛素治疗方案和降脂药物治疗，在她为期六天的住院期间，她能够将升高的甘油三酯水平从3772显著降至440。由于联合使用口服避孕药与HTG-AP之间的关系鲜为人知，本病例有助于增进对这种疾病病理生理学的理解、适当的诊断评估以及相关的治疗选择，以优化患者护理并制定有效的管理计划。通过提高对这种关联的认识，可以让患有家族性高甘油三酯血症的患者了解联合使用口服避孕药的风险，从而预防并发症并改善临床结果。
