Zhang Qian, Qian Fusheng, Cai Mengjie, Liu Ruijie, Chen Manping, Li Zhitong, Chen Ying, Lu Nannan
Department of Oncology, Affiliated Anhui Provincial Hospital, Bengbu Medical College, Bengbu, China.
Department of Oncology, The First Affiliated Hospital of USTC, Division of Life Science and Medicine, University of Science and Technology of China, Hefei, China.
Transl Cancer Res. 2024 Jul 31;13(7):3869-3888. doi: 10.21037/tcr-24-71. Epub 2024 Jul 16.
Radiation therapy (RT) is one of the important components of comprehensive treatment for breast cancer and has important value in improving the control rate of local areas, reducing the chance of recurrence and metastasis after breast cancer surgery, delaying disease progression, and improving the survival of breast cancer patients. The factors that affect the RT sensitivity of breast cancer are important. The above potential predictors of radiation efficacy can provide patients with a predictive method and therefore have significant value in clinical therapy. In this paper, we have summarised the predictive factors of radiotherapy sensitivity by reviewing recent research on breast cancer and focused on the following areas: tumor immune microenvironment (TIME), cancer stem cells, noncoding RNAs, signal transduction pathways, genes, etc. This review aims to provide theoretical basis and reference for improving the efficacy of radiotherapy and experimental individualized treatment of breast cancer.
We searched the Web of Science database to identify clinical studies published between 2010 and January 2024 that investigated radiotherapy sensitivity. The main findings of the validated studies were summarised.
Improving the radiosensitivity of breast cancer is essential in the treatment of breast cancer. The radiosensitivity can be improved by modulating immune cells or immunomodulatory factors in the TIME, modulating signal transduction pathways, and other innovative combination therapy strategies. And we also summarized the predictive markers of breast cancer radiosensitivity.
In this paper, we reviewed the literature and summarized the newest research advances on the radiosensitivity of breast cancer patients. This review paper includes the following six aspects: the immune microenvironment, tumor stem cells, signaling pathways, regulation of gene/protein expression, small molecule drugs, and predictive markers for radiosensitivity.
放射治疗（RT）是乳腺癌综合治疗的重要组成部分之一，在提高局部控制率、降低乳腺癌手术后复发和转移几率、延缓疾病进展以及提高乳腺癌患者生存率方面具有重要价值。影响乳腺癌放疗敏感性的因素至关重要。上述潜在的放疗疗效预测指标可为患者提供一种预测方法，因此在临床治疗中具有重要价值。在本文中，我们通过回顾近期关于乳腺癌的研究，总结了放疗敏感性的预测因素，并重点关注以下领域：肿瘤免疫微环境（TIME）、癌症干细胞、非编码RNA、信号转导通路、基因等。本综述旨在为提高放疗疗效及乳腺癌的实验性个体化治疗提供理论依据和参考。
我们检索了科学网数据库，以确定2010年至2024年1月期间发表的调查放疗敏感性的临床研究。总结了已验证研究的主要结果。
提高乳腺癌的放射敏感性在乳腺癌治疗中至关重要。可通过调节TIME中的免疫细胞或免疫调节因子、调节信号转导通路以及其他创新的联合治疗策略来提高放射敏感性。并且我们还总结了乳腺癌放射敏感性的预测标志物。
在本文中，我们回顾了文献并总结了乳腺癌患者放射敏感性的最新研究进展。本综述文章包括以下六个方面：免疫微环境、肿瘤干细胞、信号通路、基因/蛋白表达调控、小分子药物以及放射敏感性预测标志物。
