Department of Neurology, Chinese PLA General Hospital, Beijing 100853, China.
Department of Health Care 9, The Second Medical Centre, Chinese PLA General Hospital, Beijing 100853, China.
Nutrients. 2022 Jul 25;14(15):3052. doi: 10.3390/nu14153052.
Migraine is related to brain energy deficiency. Niacin is a required coenzyme in mitochondrial energy metabolism. However, the relationship between dietary niacin and migraines remains uncertain. We aimed to evaluate the relationship between dietary niacin and migraine. This study used cross-sectional data from people over 20 years old who took part in the National Health and Nutrition Examination Survey between 1999 and 2004, collecting details on their severe headaches or migraines, dietary niacin intake, and several other essential variables. There were 10,246 participants, with 20.1% (2064/10,246) who experienced migraines. Compared with individuals with lower niacin consumption Q1 (≤12.3 mg/day), the adjusted OR values for dietary niacin intake and migraine in Q2 (12.4−18.3 mg/day), Q3 (18.4−26.2 mg/day), and Q4 (≥26.3 mg/day) were 0.83 (95% CI: 0.72−0.97, p = 0.019), 0.74 (95% CI: 0.63−0.87, p < 0.001), and 0.72 (95% CI: 0.58−0.88, p = 0.001), respectively. The association between dietary niacin intake and migraine exhibited an L-shaped curve (nonlinear, p = 0.011). The OR of developing migraine was 0.975 (95% CI: 0.956−0.994, p = 0.011) in participants with niacin intake < 21.0 mg/day. The link between dietary niacin intake and migraine in US adults is L-shaped, with an inflection point of roughly 21.0 mg/day.
偏头痛与大脑能量不足有关。烟酸是线粒体能量代谢所必需的辅酶。然而，饮食烟酸与偏头痛之间的关系仍不确定。我们旨在评估饮食烟酸与偏头痛之间的关系。本研究使用了 1999 年至 2004 年期间参加国家健康和营养检查调查的 20 岁以上人群的横断面数据，收集了他们严重头痛或偏头痛、饮食烟酸摄入量和其他几个重要变量的详细信息。共有 10246 名参与者，其中 20.1%（2064/10246）经历过偏头痛。与烟酸摄入量较低的 Q1（≤12.3mg/天）人群相比，Q2（12.4-18.3mg/天）、Q3（18.4-26.2mg/天）和 Q4（≥26.3mg/天）的烟酸摄入量与偏头痛的校正 OR 值分别为 0.83（95%CI：0.72-0.97，p=0.019）、0.74（95%CI：0.63-0.87，p<0.001）和 0.72（95%CI：0.58-0.88，p=0.001）。饮食烟酸摄入与偏头痛之间的关系呈 L 形（非线性，p=0.011）。在烟酸摄入量<21.0mg/天的参与者中，偏头痛的发病风险比为 0.975（95%CI：0.956-0.994，p=0.011）。在美国成年人中，饮食烟酸摄入与偏头痛之间呈 L 形关系，拐点约为 21.0mg/天。
