Department of Hematology, Lishui People's Hospital, Lishui, Zhejiang, China.
Department of Traditional Chinese Medicine, FuYang Women and Children's Hospital, Fuyang, Anhui, China.
PLoS One. 2024 Aug 15;19(8):e0292569. doi: 10.1371/journal.pone.0292569. eCollection 2024.
Experimental and acute exposure studies imply that manganese affects red blood cell production. Nevertheless, the association between environmental exposure and red blood cell distribution width (RDW) has yet to be explored. This research sought to assess the correlation between blood manganese levels and RDW within the general population of the United States.
Employing weighted multiple linear regression models, data from the 2011-2018 National Health and Nutrition Examination Survey (NHANES) were utilized to assess the correlation between manganese levels in the blood and RDW. Restricted cubic spline plots and two-piecewise linear regression models were also employed.
The analysis included a total of 15882 participants in which we determined an independent positive relationship between blood manganese levels and RDW among participants(β = 0.079, P<0.001). Moreover, we identified a J-shaped association between blood manganese levels and RDW in total participants (inflection point for blood manganese: 7.32 ug/L) and distinct subgroups following adjusted covariates. Women exhibited a more pronounced association, even after controlling for adjusted covariates.
We determined a J-shaped relationship between blood manganese levels and RDW with an inflection point at 7.32 ug/L for blood manganese. Nevertheless, fundamental research and large sample prospective studies are needed to determine the extent to which blood manganese levels correlate with RDW.
实验和急性暴露研究表明，锰会影响红细胞的生成。然而，环境暴露与红细胞分布宽度（RDW）之间的关联尚未得到探索。本研究旨在评估美国普通人群中血液锰水平与 RDW 之间的相关性。
利用加权多重线性回归模型，对 2011-2018 年国家健康和营养调查（NHANES）的数据进行分析，评估血液中锰水平与 RDW 之间的相关性。还使用了限制立方样条图和两段线性回归模型。
该分析共纳入了 15882 名参与者，结果表明，参与者的血液锰水平与 RDW 之间存在独立的正相关关系（β=0.079，P<0.001）。此外，我们在总参与者（锰血拐点：7.32ug/L）和调整后的协变量后的不同亚组中发现了锰血水平和 RDW 之间的 J 形关联。在调整后的协变量后，女性表现出更为显著的关联。
我们确定了血液锰水平与 RDW 之间存在 J 形关系，血液锰的拐点为 7.32ug/L。然而，需要进行基础研究和大型样本前瞻性研究，以确定血液锰水平与 RDW 之间的相关性程度。
