Geng Rulin, Zhang Yu, Liu Miao, Deng Shengfeng, Ding Jingwen, Zhong Hongfei, Tu Qiuyun
Department of Geriatrics, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, China.
Front Aging Neurosci. 2022 Dec 8;14:1024415. doi: 10.3389/fnagi.2022.1024415. eCollection 2022.
The many studies revealing a connection between serum uric acid (SUA) and dementia have reported conflicting results. This study sought to investigate the relations between SUA and cognitive function in older adults.
The sample was 2,767 American adults aged ≥60 years from the National Health and Nutrition Examination Survey 2011-2014. Cognitive performance was evaluated by the Consortium to Establish a Registry for Alzheimer's Disease test, animal fluency test, digit symbol substitution test, and composite z-score. Multivariate linear regression analyses were conducted to estimate the association between SUA and cognitive function.
SUA level and cognitive function were significantly, positively correlated. Age significantly correlated with the association between SUA and cognitive function.
These findings support a connection between SUA and cognition, showing a positive link between SUA and cognitive scores among older American adults. We contend that a slight rise in uric acid within the normal range is advantageous for enhanced cognition. To confirm the precise dose-time-response relation, more tests will be needed.
许多研究揭示了血清尿酸（SUA）与痴呆症之间的联系，但报告结果相互矛盾。本研究旨在调查老年人中SUA与认知功能之间的关系。
样本来自2011 - 2014年美国国家健康与营养检查调查，共2767名年龄≥60岁的美国成年人。认知表现通过阿尔茨海默病注册协会测试、动物流畅性测试、数字符号替换测试和综合z分数进行评估。进行多变量线性回归分析以估计SUA与认知功能之间的关联。
SUA水平与认知功能显著正相关。年龄与SUA和认知功能之间的关联显著相关。
这些发现支持SUA与认知之间的联系，表明美国老年成年人中SUA与认知得分之间存在正相关。我们认为，正常范围内尿酸的轻微升高有利于增强认知。为了确认精确的剂量 - 时间 - 反应关系，还需要更多测试。
