拟杆菌酸产生菌驱动肝脏解毒程序。
Bacteroides acidifaciens drives a liver detox program.
机构信息
Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China; National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China; Hubei Key Laboratory of Hepato-Pancreatic-Biliary Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China; Hubei Key Laboratory of Hepato-Pancreatic-Biliary Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
出版信息
Cell Host Microbe. 2024 Aug 14;32(8):1212-1214. doi: 10.1016/j.chom.2024.07.011.
Alcohol-associated liver disease is a leading cause of chronic liver conditions, yet there are limited effective therapies. In this issue of Cell Host & Microbe, Shen et al. demonstrate that soluble dietary fiber enhances intestinal Bacteroides acidifaciens, which ameliorates alcohol-associated liver injury in mice by activating hepatic ornithine aminotransferase.
酒精性肝病是慢性肝脏疾病的主要原因，但目前有效的治疗方法有限。在本期《Cell Host & Microbe》杂志上，Shen 等人证明，可溶性膳食纤维可增强肠道拟杆菌的生长，通过激活肝脏鸟氨酸转氨酶来改善小鼠的酒精性肝损伤。
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