拟杆菌酸产生菌：将膳食纤维与肝脏健康联系起来。

Bacteroides acidifaciens: Linking dietary fiber to liver health.

机构信息

Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg.

Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg; Department of Life Sciences and Medicine, Faculty of Science, Technology and Medicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg.

出版信息

Cell Metab. 2024 Sep 3;36(9):1908-1910. doi: 10.1016/j.cmet.2024.08.002.

DOI:10.1016/j.cmet.2024.08.002

PMID:39232278

Abstract

While innumerous associative microbiome studies have been published, mechanistic links between the microbiome and host physiology remain much scarcer. In Cell Host & Microbe, Shen et al. report the effect of soluble dietary fibers in alcohol-related liver disease. Through microbiome remodeling, dietary fiber triggers upregulation of liver ornithine aminotransferase and a subsequent reduction in hepatic damage.

摘要

虽然已经发表了无数项关于微生物组的关联研究，但微生物组与宿主生理学之间的机制联系仍然很少。在《Cell Host & Microbe》杂志上，沈等人报告了可溶性膳食纤维在酒精性肝病中的作用。通过微生物组重塑，膳食纤维触发肝脏鸟氨酸转氨酶的上调，随后减少肝损伤。