Department of Plastic and Aesthetic Surgery, Nanfang Hospital of Southern Medical University, Guangzhou, Guangdong Province 510515, China.
University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Cell Host Microbe. 2024 Aug 14;32(8):1264-1279. doi: 10.1016/j.chom.2024.07.020.
Human skin is the host to various commensal microbes that constitute a substantial microbial community. The reciprocal communication between these microbial inhabitants and host cells upholds both the morphological and functional attributes of the skin layers, contributing indispensably to microenvironmental and tissue homeostasis. Thus, disruption of the skin barrier or imbalances in the microbial communities can exert profound effects on the behavior of host cells. This influence, mediated by the microbes themselves or their metabolites, manifests in diverse outcomes. In this review, we examine existing knowledge to provide insight into the nuanced behavior exhibited by the microbiota on skin cells in health and disease states. These interactions provide insight into potential cellular targets for future microbiota-based therapies to prevent and treat skin disease.
人体皮肤是各种共生微生物的宿主，这些微生物构成了一个庞大的微生物群落。这些微生物居民与宿主细胞之间的相互交流维持着皮肤各层的形态和功能属性，对微环境和组织稳态起着不可或缺的作用。因此，皮肤屏障的破坏或微生物群落的失衡都会对宿主细胞的行为产生深远的影响。这种影响是由微生物本身或其代谢物介导的，表现出多种结果。在这篇综述中，我们检查了现有的知识，以深入了解微生物群在健康和疾病状态下对皮肤细胞表现出的细微行为。这些相互作用为基于微生物组的未来治疗方法提供了潜在的细胞靶点，以预防和治疗皮肤疾病。
