体细胞突变的基因组模式为癌症提供了新的预后、治疗和生物学见解。
Genomic patterns of somatic mutations provide new prognostic, therapeutic, and biological insights in cancer.
机构信息
The Department of Microbiology and Molecular Genetics, Institute for Medical Research Israel-Canada, The Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.
The Department of Microbiology and Molecular Genetics, Institute for Medical Research Israel-Canada, The Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.
出版信息
Cell Genom. 2024 Aug 14;4(8):100635. doi: 10.1016/j.xgen.2024.100635.
The mutational landscape of an individual's cancer can inform on its molecular state and be used as prognostic and therapeutic markers. The study by Barbour et al. analyzes mutational patterns in bladder cancer samples to uncover new biological insights into the ERCC2 gene function and develop new predictive prognostic tools.
个体癌症的突变情况可以反映其分子状态，并可作为预后和治疗标志物。Barbour 等人的研究分析了膀胱癌样本中的突变模式，以揭示 ERCC2 基因功能的新生物学见解，并开发新的预测预后工具。
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