Guangzhou Stars Pulse Co., Ltd., Guangzhou, Guangdong, China.
School of Pharmaceutical Sciences (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Shenzhen, Guangdong 518107, China; College of Life Sciences, Northwest A&F University, Yangling, Shaanxi 712100, China.
J Photochem Photobiol B. 2024 Oct;259:113008. doi: 10.1016/j.jphotobiol.2024.113008. Epub 2024 Aug 10.
Androgenic alopecia (AGA) typically manifests post-puberty, resulting in decreases in hair density, disruptions in the hair growth cycle, and alterations in hair follicle micro structure. Dihydrotestosterone (DHT) is a key hormone implicated in hair loss, especially on male. In this study, we found that each of arginine (Arg), arterial extract (AE) or biotin tripeptide-1 (BT-1), when combined with low level light therapy (LLLT, at 630 nm, 2 J/cm), showed the efficacy in enhancing mitochondrial functions, cell proliferation and collagen synthesis in fibroblasts. Additionally, CARRIPOWER (the complexes of AE, BT-1, Arg, and Diaminopyrimidine derivatives), in conjunction with LLLT (630 nm, 2 J/cm), showed promising results in dermal papilla cells (DPCs). The promising results contained not also inflammatory cytokines (IL-1β and IL-6) and cell pro apoptotic factor (TGF-β2) reduction, but also Wnt pathway inhibition by decreasing DKK1 level, and pro-hair growth factors (vascular endothelial growth factor (VEGF) and β-catenin) increase. This innovative combination therapy offers a potential solution for the treatment of AGA, addressing both hormonal and cellular factors involved in hair loss.
雄激素性脱发（AGA）通常在青春期后出现，导致头发密度下降、毛发生长周期紊乱和毛囊微结构改变。双氢睾酮（DHT）是一种与脱发密切相关的关键激素，尤其是在男性中。在这项研究中，我们发现精氨酸（Arg）、动脉提取物（AE）或生物素三肽-1（BT-1）各自与低水平光疗（LLLT，630nm，2J/cm）联合使用时，均能有效增强成纤维细胞的线粒体功能、细胞增殖和胶原蛋白合成。此外，CARRIPOWER（AE、BT-1、Arg 和二氨基嘧啶衍生物的复合物）与 LLLT（630nm，2J/cm）联合使用时，在真皮乳头细胞（DPC）中显示出有希望的结果。这些有希望的结果不仅包括炎症细胞因子（IL-1β和 IL-6）和细胞促凋亡因子（TGF-β2）的减少，还包括通过降低 DKK1 水平抑制 Wnt 通路和增加促毛发生长因子（血管内皮生长因子（VEGF）和 β-连环蛋白）。这种创新的联合治疗为 AGA 的治疗提供了一种潜在的解决方案，针对涉及脱发的激素和细胞因素。
