Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, USA.
Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, USA.
J Affect Disord. 2024 Nov 15;365:400-405. doi: 10.1016/j.jad.2024.08.066. Epub 2024 Aug 13.
Little is known about rates of COVID-19 vaccine uptake among youth with bipolar spectrum disorders (BSD). As such, the aim of this study is to assess rates and predictors of COVID-19 vaccine uptake among youth with BSD and their caregivers in the United States.
Youth and their main caregiver were recruited from a large pragmatic study cohort. Youth who were aged 8-22 at the time of this data collection, had a bipolar-spectrum disorder diagnosis, had overweight or obesity, and were treated with a second-generation antipsychotic were invited to participate in an online survey and interview assessing the impact of the COVID-19 pandemic.
A total of 453 surveys and 341 interviews were completed 07/2021-05/2022 by youth and their caregivers. Sixty-seven percent of caregivers and 63 % of youth reported receiving the COVID-19 vaccine. Vaccine uptake rates among youth and caregivers were highly correlated. Predictors of vaccine uptake among youth were older age and living in the Northeast Region of the United States. Predictors of caregiver vaccine uptake were male sex, higher annual household income and not having to quarantine due to COVID-19.
The sample was small and not a full representation of a population with bipolar-spectrum disorders therefore, the results may not be generalizable. The study design and statistical method do not allow for causal inferences to be made.
These findings may aid in targeting interventions to maximize COVID-19 and other vaccine uptake in youth with bipolar disorders and their families.
目前对于双相谱系障碍（BSD）青少年的 COVID-19 疫苗接种率知之甚少。因此，本研究旨在评估美国 BSD 青少年及其照顾者 COVID-19 疫苗接种率及其预测因素。
从一项大型实用研究队列中招募了青少年及其主要照顾者。在本次数据收集时年龄在 8-22 岁、患有双相谱系障碍诊断、超重或肥胖、并接受第二代抗精神病药物治疗的青少年被邀请参加一项在线调查和访谈，评估 COVID-19 大流行的影响。
2021 年 7 月至 2022 年 5 月，共有 453 份调查和 341 份访谈由青少年及其照顾者完成。67%的照顾者和 63%的青少年报告接种了 COVID-19 疫苗。青少年和照顾者的疫苗接种率高度相关。青少年疫苗接种的预测因素是年龄较大和居住在美国东北部地区。照顾者疫苗接种的预测因素是男性、较高的家庭年收入和因 COVID-19 而无需隔离。
样本较小，不能代表所有 BSD 人群，因此结果可能不具有普遍性。研究设计和统计方法不允许进行因果推断。
这些发现可能有助于针对干预措施，最大限度地提高患有双相障碍的青少年及其家庭对 COVID-19 和其他疫苗的接种率。
