School of Public Health, Jining Medical University, Jining, Shandong, China; Department of Hematology, The Affiliated Tai'an City Central Hospital of Qingdao University, Tai'an, Shandong, China.
School of Public Health, Jining Medical University, Jining, Shandong, China; School of Public Health, Binzhou Medical University, Yantai, Shandong, China.
J Affect Disord. 2024 Nov 15;365:171-177. doi: 10.1016/j.jad.2024.08.065. Epub 2024 Aug 13.
Rs768705 (TMEM161B) is one of the identified single nucleotide polymorphisms related to major depressive disorder (MDD). Paranoid personality traits are independently associated with the risk of MDD. This study aimed to investigate the interaction effect between rs768705 (TMEM161B) and paranoid personality traits on the new-onset risk of MDD in Chinese freshmen.
A longitudinal study was conducted among 7642 Chinese freshmen without lifetime MDD at baseline in 2018. 158 new-onset MDD cases were ascertained in 2019. DNA samples were extracted to detect the genotype of rs768705. The diagnostic and statistical manual of mental disorders-IV criteria were used to determine MDD and personality disorder traits. Multiplicative interaction was assessed by logistic regression models. Tomas Andersson's method for calculating biological interactions was used to estimate the additive interaction.
Rs768705(AG) (OR = 1.88, 95 % CI: 1.24-2.83) and paranoid personality traits (OR = 3.68, 95 % CI: 2.57-5.26) were significantly associated with the risk of MDD. The multiplicative interaction model with the product term of rs768705 and paranoid personality trait traits had a significant interaction effect (OR = 4.20, 95 % CI:1.62-10.91). There was also a significant additive interaction effect (RR = 7.08, 95 % CI:4.31-11.65) for the incidence of MDD. Seventy seven percent patients among new MDD cases were attributed to the additive interaction effect between rs768705 and paranoid personality traits.
Rs768705 (AG) may interact with paranoid personality traits to increase the incidence of MDD among Chinese college students. Schools and psychosocial health organizations should pay more attention to individuals with paranoid personality traits for MDD intervention and prevention.
Rs768705（TMEM161B）是与重度抑郁症（MDD）相关的单核苷酸多态性之一。偏执型人格特质与 MDD 的发病风险独立相关。本研究旨在探讨 rs768705（TMEM161B）与偏执型人格特质之间的相互作用对中国大一新生 MDD 新发病风险的影响。
在 2018 年对 7642 名无终生 MDD 的中国大一新生进行了一项纵向研究。2019 年确定了 158 例新发 MDD 病例。提取 DNA 样本检测 rs768705 的基因型。采用《精神障碍诊断与统计手册》第四版标准确定 MDD 和人格障碍特征。采用 logistic 回归模型评估乘法交互作用。采用 Tomas Andersson 方法计算生物交互作用来估计加性交互作用。
rs768705（AG）（OR=1.88，95%CI：1.24-2.83）和偏执型人格特质（OR=3.68，95%CI：2.57-5.26）与 MDD 风险显著相关。rs768705 与偏执型人格特质乘积项的乘法交互模型具有显著的交互作用（OR=4.20，95%CI：1.62-10.91）。MDD 的发生率也存在显著的加性交互作用（RR=7.08，95%CI：4.31-11.65）。新 MDD 病例中有 77%归因于 rs768705 与偏执型人格特质之间的加性交互作用。
rs768705（AG）可能与偏执型人格特质相互作用，增加中国大学生 MDD 的发病率。学校和社会心理健康组织应更加关注偏执型人格特质的个体，以进行 MDD 的干预和预防。
